A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases
A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases
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DOI：
10.1194/jlr.e500003-jlr200
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发表时间：
2005-09-01
影响因子：
6.5
通讯作者：
Alexson, SEH
中科院分区：
文献类型：
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作者：
Hunt, MC;Yamada, J;Alexson, SEH
酰基-COA硫酯酶，也称为酰基-COA水解酶，是一组酶，水解胶质酯（如酰基-COA（饱和，不饱和，分支），胆汁酸-COAS，Prostaglandins的COA酯，胆汁酸酸酯等相应的游离酸和COA。但是，这些基因的命名法存在很大的混乱。与Hugo Gene命名委员会和小鼠基因组命名委员会一致，这是为12个成员家族的修订型哺乳动物酰基酰辅酶A硫酯酶/水解酶的修订命名法。家族根符号是ACOT，其人类基因称为ACOT1-ACOT12，而大鼠和小鼠基因称为ACOT1-ACOT12。几个ACOT基因是剪接事件的结果，并且这些剪接变体被分类。
Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated, branchedchain), bile acid-CoAs, CoA esters of prostaglandins, etc., to the corresponding free acid and CoA. However, there is significant confusion regarding the nomenclature of these genes. In agreement with the HUGO Gene Nomenclature Committee and the Mouse Genomic Nomenclature Committee, a revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases has been suggested for the 12 member family. The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12. Several of the ACOT genes are the result of splicing events, and these splice variants are cataloged.