Role of fine needle aspiration cytology in the diagnosis of soft tissue tumours and tumour-like lesions
Role of fine needle aspiration cytology in the diagnosis of soft tissue tumours and tumour-like lesions
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DOI：
10.1046/j.0956-5507.2003.00102.x
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发表时间：
2004-02-01
期刊：
影响因子：
1.3
通讯作者：
Vasishta, RK
中科院分区：
文献类型：
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作者：
Dey, P;Mallik, MK;Vasishta, RK
在这项研究中，我们评估了细针穿刺细胞学（FNAC）在软组织肿瘤诊断中的作用。我们还评估了软组织肿瘤FNAC的各种陷阱。这是一项回顾性研究，在这里，我们分析了只有82个组织病理学证实的情况下，FNAC的软组织肿瘤诊断在五年半的时间。组织病理学检查，其中55例为恶性，27例为良性。共有15例复发，其中仅8例在FNAC前可获得组织病理学检查。因此，排除这8例病例，47例病例经细针吸取细胞学初步诊断为恶性肿瘤。FNAC诊断软组织肿瘤的敏感性、特异性和阳性预测值分别为91.5%、92.5%和95.5%。47例中只有22例（46.8%）被正确分类。有2例假阳性和4例假阴性病例。纤维瘤病和神经鞘瘤各有1例报告为肉瘤。假阴性病例为纤维肉瘤（1例）、恶性神经鞘瘤（2例）和血管外皮细胞瘤（1例）。细针吸取细胞学检查对鉴别软组织肿瘤的良恶性有重要意义。然而，它在肿瘤的准确分类方面并不那么有效。
In this study, we evaluated the usefulness of fine needle aspiration cytology (FNAC) in the diagnosis of soft tissue tumours. We have also assessed the various pitfalls of FNAC of soft tissue tumours. This was a retrospective study and here we analysed only 82 histopathology proven cases of FNAC of soft tissue tumours diagnosed in a five and half year period. On histopathological examination, 55 of these cases were malignant and 27 were benign. There was a total of 15 recurrences and histopathology was available prior to FNAC in only eight of these cases. Therefore, excluding these eight cases, malignant tumours were primarily diagnosed by FNAC in 47 cases. The sensitivity, specificity and positive predictive value of FNAC in diagnosis of soft tissue tumours were 91.5%, 92.5% and 95.5%, respectively. Only 22 of 47 cases (46.8%) were correctly categorized. There were two false-positive and four false-negative cases. One case each of fibromatosis and schwannoma were reported as sarcoma. False-negative cases were fibrosarcoma (1), malignant nerve sheath tumour (2) and haemangiopericytoma (1). FNAC was very useful in distinguishing benign from malignant soft tissue tumours. However, it was not so effective in exact categorization of tumours.