Physalis alkekengi var. franchetii Extracts Exert Antitumor Effects on Non-Small Cell Lung Cancer and Multiple Myeloma by Inhibiting STAT3 Signaling.
Physalis alkekengi var. franchetii Extracts Exert Antitumor Effects on Non-Small Cell Lung Cancer and Multiple Myeloma by Inhibiting STAT3 Signaling.
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酸浆 alkekengi var.
DOI：
10.2147/ott.s282334
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发表时间：
2021
影响因子：
4
通讯作者：
Shen L
中科院分区：
文献类型：
--
作者：
Fu Y;Zhu F;Ma Z;Lv B;Wang X;Dai C;Ma X;Liu P;Lv H;Chen X;Chen Z;Shen L
酸浆（Physalis alkekengi var. franchetii）是一种具有多种民族药理学用途的草本植物。在此，我们当前的研究聚焦于酸浆苦素组合的抗肿瘤作用，酸浆苦素被视为酸浆花萼中最具代表性的次生代谢产物。
我们主要研究了从酸浆中提取的酸浆苦素对实体癌和血液癌的抗肿瘤活性。本研究使用的主要细胞为NCI - H1975和U266细胞。所采用的主要实验方法有CCK - 8检测、蛋白质免疫印迹分析、免疫荧光检测和膜联蛋白V检测，并使用了异种移植小鼠模型。
结果显示，酸浆苦素通过抑制组成型信号转导及转录激活因子3（STAT3）的活性，进而抑制STAT3信号通路诱导的下游靶基因表达，对非小细胞肺癌（NSCLC）和多发性骨髓瘤（MM）细胞均表现出强大的抗肿瘤作用，从而增强肿瘤细胞的凋亡。此外，酸浆苦素在肺癌异种移植模型中显著抑制了肿瘤生长。
总体而言，这些研究结果表明，酸浆中的酸浆苦素可能通过抑制STAT3信号通路，潜在地成为NSCLC和MM的癌症预防或化疗药物。本研究为进一步探索酸浆在癌症治疗中的精确机制提供了有前景的指导。
Physalis alkekengi var. franchetii is an herb that possesses various ethnopharmacological applications. Herein, our current study focuses on the antitumor effect of a combination of physalins, which are regarded as the most representative secondary metabolites from calyces of Physalis alkekengi var. franchetii. We mainly investigated the antitumor activity of the physalins extracted from Physalis alkekengi var. franchetii on both solid and hematologic cancers. The main cells used in this study were NCI-H1975 and U266 cells. The major assays used were the CCK-8 assay, Western blot analyses, immunofluorescence assay and Annexin V assay, and a xenograft mouse model was used. The results showed that physalins exhibited a strong antitumoural effect on both non-small cell lung cancer (NSCLC) and multiple myeloma (MM) cells by suppressing constitutive STAT3 activity and further inhibiting the downstream target gene expression induced by STAT3 signaling, which resulted in the enhanced apoptosis of tumor cells. Moreover, physalins significantly reduced tumor growth in xenograft models of lung cancer. Collectively, these findings demonstrated that the physalins from Physalis alkekengi var. franchetii may potentially act as cancer preventive or chemotherapeutic agents for NSCLC and MM by inhibiting the STAT3 signaling pathway. The present study served as a promising guide to further explore the precise mechanism of Physalis alkekengi var. franchetii in cancer treatment.