Prominent Anti-UV Activity and Possible Cosmetic Potential of Lignin-carbohydrate Complex.
Prominent Anti-UV Activity and Possible Cosmetic Potential of Lignin-carbohydrate Complex.
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发表时间：
2016-07
期刊：
影响因子：
2.3
通讯作者：
H. Sakagami;Hong Sheng;N. Okudaira;T. Yasui;H. Wakabayashi;Junye Jia;T. Natori;Madoka Suguro-Kitajima;H. Ōizumi;Takaaki Oizumi
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作者：
H. Sakagami;Hong Sheng;N. Okudaira;T. Yasui;H. Wakabayashi;Junye Jia;T. Natori;Madoka Suguro-Kitajima;H. Ōizumi;Takaaki Oizumi
本文综述了近年来紫外线防护物质的研究进展，包括我们的原始报道。我们建立了一个简单的测定方法，用于测定抗紫外线活性，可以适用于任何类型的贴壁细胞。该方法提供了任何类型样品的抗UV活性和细胞毒性的信息，即使这些样品含有未知量的测试化合物。我们发现，木质素碳水化合物复合物（LCC）显示出一个或两个订单较高的抗紫外线活性相比，众所周知的低分子量多酚和热水提取物的汉方药物和茶叶。在合成的化合物中，水溶性的甘菊环类化合物表现出最高的抗紫外活性。LCC与维生素C具有相加或协同的抗紫外线活性。碱提取物Sasa senanensis叶（SE），一个LCC丰富的非处方药（OTC），也显示出强大的抗病毒和维生素C协同自由基清除活性。SE已用于生产牙膏、肥皂和凝胶化妆品，以提高生活质量（QOL）水平。
This review article summarizes the recent progress of ultraviolet rays (UV) protective substances, including our original reports. We have established a simple assay method for the determination of anti-UV activity that can be applicable to any kind of adherent cells. This method provides information of both anti-UV activity and cytotoxicity of any kind of samples even though those samples contain unknown amounts of test compounds. We found that lignin-carbohydrate complex (LCC) showed one- or two-order higher anti-UV activity compared to well-known lower molecular weight polyphenols and hot-water extracts of Kampo medicines and tea leaves. Among synthetic compounds, water-soluble azulenes showed the highest anti-UV activity. LCC showed additive or synergistic anti-UV activity with vitamin C. Alkaline extract of Sasa senanensis Rehder leaves (SE), an LCC-rich over-the-counter (OTC) drug, also showed potent antiviral and vitamin C-synergized radical scavenging activity. SE has been utilized to manufacture tooth paste, soap and gel cosmetic to increase the level of quality of life (QOL).