Sex hormones and age: a cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men.
Sex hormones and age: a cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men.
复制标题
性激素和年龄：社区男性睾酮和雌二醇及其生物利用度的横断面研究。
DOI：
10.1093/oxfordjournals.aje.a009519
复制
发表时间：
1998
影响因子：
5
通讯作者：
Barrett-Connor,E
中科院分区：
文献类型：
--
作者：
Ferrini,RL;Barrett-Connor,E
内源性激素在许多疾病中的作用使得了解影响这些激素水平的因素变得越来越重要。本研究探讨了与年龄相关的变化，总的和生物可利用的睾酮和雌二醇水平之间的社区居住在兰乔贝尔纳多，加州的白人男子。1993年用放射免疫分析法分析了1984-1987年间810例24-90岁男性的血浆样品。年龄激素协会的分析，调整体重，体重指数，酒精摄入，吸烟，体力活动，咖啡因摄入量，标本储存时间和疾病状态，进行。生物可利用睾酮和生物可利用雌二醇水平随年龄显著下降，与协变量无关。总睾酮和雌二醇水平随着年龄的增长而下降，只有当分析控制了混杂因素。与年龄相关的内源性性激素水平下降的重要性，特别是生物可利用的睾酮和生物可利用的雌二醇的水平，以及它们与男性疾病和功能的关系值得进一步研究。Am J Epidemiol 1998;147：750-4。
The role of endogenous sex hormones in many diseases makes understanding factors that influence levels of these hormones increasingly important. This study examined age-associated variations in total and bioavailable testosterone and estradiol levels among community-dwelling Caucasian men in Rancho Bernardo, California. Plasma samples obtained from 810 men aged 24–90 years in 1984–1987 were analyzed in 1993 using radioimmunoassay. Analyses of age-hormone associations, adjusting for weight, body mass index, alcohol ingestion, smoking, physical activity, caffeine intake, specimen storage time, and disease status, were undertaken. Bioavailable testosterone and bioavailable estradiol levels decreased significantly with age independently of covariates. Total testosterone and estradiol levels decreased with age only when analyses were controlled for confounders. The importance of the age-associated decline in endogenous sex hormone levels, particularly levels of bioavailable testosterone and bioavailable estradiol, and their relation to disease and function in men deserve further research.Am J Epidemiol1998;147:750–4.