The GRAFT-VERSUS-HOST DISEASE IN CHILDREN WHO HAVE RECEIVED A CORD-BLOOD OR BONE MARROW TRANSPLANT FROM AN HLA-IDENTICAL SIBLING
The GRAFT-VERSUS-HOST DISEASE IN CHILDREN WHO HAVE RECEIVED A CORD-BLOOD OR BONE MARROW TRANSPLANT FROM AN HLA-IDENTICAL SIBLING
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发表时间：
2000
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通讯作者：
Athleen;S. A.;Obocinski;ohn;K. P;Lein
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作者：
Athleen;S. A.;Obocinski;ohn;K. P;Lein
作为替代干细胞风险的调理方案；GVHD的预防类型；使用或不使用粒细胞集落刺激因子、粒细胞-巨噬细胞集落刺激因子，或两者兼而有之，以加速中性粒细胞的恢复；注入有核细胞的剂量。在最终模型中只保留与结果显著相关的因素（P<0.05）。最终模型中缺少一个因素表明，与所描述的结果的风险没有显著关联。协变量方面，使用时间相关协变量对比例风险假设进行了检验。当试验表明差异效应大于（非比例危害）时，我们构建了将移植后的时间间隔划分为两个时期的模型，并使用最大部分似然方法找到最合适的断点。对于这些变量，我们确定了每个时期的相对风险。采用前向逐步选择显著性水平小于0.05的变量的方法来识别除移植物类型外与预后相关的协变量。在每一步中，移植类型的协变量都包含在模型中。考虑了接枝类型和显著协变量之间的一阶相互作用。我们用Wald检验检验协变量的综合效应。为了确定移植中心的效果，我们测试了一个随机效应模型21；没有证据表明与中心相关的影响混淆了我们之前的发现。所有P值都是双面的。
as an alternative for stem-cell risk of the conditioning regimen; the type of prophylaxis against GVHD; the use or nonuse of granulocyte colony-stimulating factor, gran-ulocyte–macrophage colony-stimulating factor, or both to hasten the recovery of neutrophils; and the dose of nucleated cells infused. Only factors significantly associated with an outcome (P<0.05) were retained in the final models. The absence of a factor from the final models indicates that there was no significant association with the risk of the outcome described. and covariate, the assumption of proportional hazards was tested with use of time-dependent covariates. When the test indicated differential effects over (nonproportional hazards), we constructed models in which the interval after transplantation was divided into two periods, and we used the maxi- mized partial-likelihood method to find the most appropriate break-point. 20 For these variables, we determined the relative risks for each of the periods. A forward stepwise method of selecting variables at a significance level of less than 0.05 was used to identify covariates other than the type of graft that were associated with outcome. In each step, the covariate for the type of graft was in- cluded in the model. First-order interactions between the type of graft and significant covariates were considered. We tested the over- all effects of covariates using Wald’s test. To determine the effects of the transplantation center, we tested a random-effects model 21 ; there was no evidence that center-related effects confounded our previous findings. All P values are two-sided.