An Update of Research Animal Models of Inflammatory Bowel Disease.
An Update of Research Animal Models of Inflammatory Bowel Disease.
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DOI：
10.1155/2021/7479540
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发表时间：
2021
影响因子：
--
通讯作者：
Zaid Y
中科院分区：
文献类型：
--
作者：
Baydi Z;Limami Y;Khalki L;Zaid N;Naya A;Mtairag EM;Oudghiri M;Zaid Y
炎症性肠病（IBD）是一组慢性疾病，包括两种主要的疾病形式，克罗恩病和溃疡性结肠炎。随着众多小鼠肠道炎症模型的发展，对IBD中发生的肠道炎症的理解已经得到了不可估量的推进。这种研究工具在IBD中的有用性源于潜在的遗传易感性、免疫系统功能障碍、环境因素和肠道微生物群变化的趋同。由于这些疾病的多因素特征，不同的动物模型被用来研究潜在的机制和开发潜在的治疗策略。临床前疗效研究的结果通常为治疗策略的进展提供信息。本文描述了每种小鼠IBD模型的独特特征和局限性，并讨论了以往和当前IBD模型的经验教训。
Inflammatory bowel disease (IBD) is a group of chronic disorders that includes two main disease forms, Crohn's disease, and ulcerative colitis. The understanding of the intestinal inflammation occurring in IBD has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation. The usefulness of this research tool in IBD arises from a convergence of underlying genetic susceptibility, immune system dysfunction, environmental factors, and shifts in gut microbiota. Due to the multifactorial feature of these diseases, different animal models have been used to investigate the underlying mechanisms and develop potential therapeutic strategies. The results of preclinical efficacy studies often inform the progression of therapeutic strategies. This review describes the distinct feature and limitations of each murine IBD model and discusses the previous and current lessons from the IBD models.