Saccade eye movements as a quantitative measure of frontostriatal network in children with ADHD
Saccade eye movements as a quantitative measure of frontostriatal network in children with ADHD
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DOI：
10.1016/j.braindev.2009.04.017
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发表时间：
2010-05-01
影响因子：
1.7
通讯作者：
Aihara, Masao
中科院分区：
文献类型：
--
作者：
Goto, Yusuke;Hatakeyama, Kazuo;Aihara, Masao
背景：注意缺陷多动障碍(ADHD)抑制不良的证据主要来自神经心理学任务和神经成像研究，其中许多研究揭示了额纹状体网络结构/功能的异常，具有去抑制和抑制相反的功能。因此，对眼跳的研究有助于了解ADHD的病理生理学基础。目的：探讨正常儿童的反射性/自愿性眼跳控制的发展，比较ADHD组和对照组的眼跳参数，阐明ADHD的神经系统功能障碍。方法：研究对象包括50例正常人(6~35岁)、19例ADHD患者(6~11岁)和4例额叶病变患者(13~15岁)。在所有眼跳任务中计算眼跳潜伏期和准确度，在记忆引导的眼跳任务中计算预期错误百分比(PAE)，在反眼跳任务中计算方向错误百分比(PDE)。结果：在正常对照组中，眼跳潜伏期、眼跳准确率、错误率与年龄显著相关。DHD儿童和6-8岁儿童在眼跳潜伏期和准确性方面存在显著差异。ADHD组的PAE和PDE发生率显著高于对照组。额叶病变患者的PAE和PDE显著高于额叶病变患者。结论：这些结果表明，眼球跳动直到青春期才完全成熟，ADHD患者表现出“反应抑制”功能障碍，该功能受额叶，特别是前额叶、扣带回和基底节的调节。(C)2009爱思唯尔B.V.保留所有权利。
Background: Evidence of poor inhibition in attention deficit hyperactivity disorder (ADHD) comes primarily from neuropsychological tasks and neuroimaging studies, many of which have revealed structural/functional abnormalities of the frontostriatal network with opposing functions of disinhibition and inhibition. Studies of saccades have therefore contributed to the understanding of the pathophysiological basis of ADHD. Object: To investigate the development of reflexive/voluntary control of saccades in normal children, compare saccade parameters between ADHD and control groups, and clarify dysfunctional nervous systems in ADHD. Methods: Subjects comprised 50 normal subjects (6-35 years), 19 ADHD patients (6-11 years) and four patients with frontal lesions (13-15 years). Saccade latency and accuracy were computed in all saccade tasks, while percentage of anticipatory errors (PAE) was determined in memory-guided saccade task, and percentage of direction errors (PDE) was determined in antisaccade task. Results: In normal controls, significant correlations were observed between saccade latency, saccade accuracy, error rates and age. Significant differences existed between A DHD and 6- to 8-year-old controls in saccade latency and accuracy. The ADHD group showed significantly higher PAE and PDE rates than controls. Patients with frontal lesions showed significantly higher PAE and PDE. Conclusions: These results suggest that saccade eye movements do not fully mature until adolescence, and that ADHD patients show dysfunction in "response inhibition", which is modulated by the frontal lobe, particularly the prefrontal cortex, cingulate cortex and basal ganglia. (c) 2009 Elsevier B.V. All rights reserved.