Hydrophilic Fluorescent Nanogel Thermometer for Intracellular Thermometry
Hydrophilic Fluorescent Nanogel Thermometer for Intracellular Thermometry
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DOI：
10.1021/ja807714j
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发表时间：
2009-03-04
影响因子：
15
通讯作者：
Uchiyama, Seiichi
中科院分区：
文献类型：
--
作者：
Gota, Chie;Okabe, Kohki;Uchiyama, Seiichi
描述了测量细胞内温度的第一种方法。为此开发的高亲水性荧光纳米凝胶温度计停留在细胞质中，在更高的温度下发出更强的荧光。因此，与生物过程相关的细胞内温度变化可以通过这种新型温度计监测，其温度分辨率优于0.5 ℃。
The first methodology to measure intracellular temperature is described. A highly hydrophilic fluorescent nanogel thermometer developed for this purpose stays in the cytoplasm and emits stronger fluorescence at a higher temperature. Thus, intracellular temperature variations associated with biological processes can be monitored by this novel thermometer with a temperature resolution of better than 0.5 degrees C.