ANXIOGENIC EFFECTS OF METHYL-BETA-CARBOLINE-3-CARBOXYLATE IN A LIGHT DARK CHOICE SITUATION
ANXIOGENIC EFFECTS OF METHYL-BETA-CARBOLINE-3-CARBOXYLATE IN A LIGHT DARK CHOICE SITUATION
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DOI：
10.1016/0091-3057(87)90006-2
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发表时间：
1987-09-01
影响因子：
3.6
通讯作者：
CHAPOUTHIER, G
中科院分区：
文献类型：
--
作者：
BELZUNG, C;MISSLIN, R;CHAPOUTHIER, G
苯二氮卓、氯拉卓酯以及苯二氮卓受体β-受体的反向激动剂的剂量CCM，未能呈现镇静或发作后抑郁的影响，首先确定在一个自由的探索情况。然后，观察以1.0、2.0和4.0 mg/kg剂量给药的氯拉卓酸和β-羟丁酸的作用。在明/暗箱选择程序中研究了1.0和2.5 mg/kg剂量的CCM。氯拉卓酸倾向于增加小鼠在照明箱中花费的时间以及两个箱之间的转换次数，而1.0 mg/kg的β-氯拉卓酸的剂量CCM具有相反的效果。苯并二氮杂拮抗剂RO 15-1788完全抵消了以2.0 mg/kg剂量给药的氯拉卓酯的抗焦虑作用和β-羟苯甲酰胺的致焦虑作用。CCM.
Doses of benzodiazepine, clorazepate, and also of the inverse agonist of the benzodiazepine receptor, .beta.-CCM, which failed to present sedative or postictal depressive effects, were at first determined in a free exploratory situation. Then, the effects of clorazepate dosed at 1.0, 2.0 and 4.0 mg/kg and .beta.-CCM dosed at 1.0 and 2.5 mg/kg were studied in the light/dark box choice procedure. Clorazepate tended to produce an increase of the time spent by mice in the lit box as well as of the number of transitions between the two boxes, whereas the dose of 1.0 mg/kg of .beta.-CCM had opposite effects. The benzodiazepine antagonist RO 15-1788 completely counteracted the anxiolytic effects of clorazepate dosed at 2.0 mg/kg and the anxiogenic effects of .beta.-CCM.