Dual-responsive aggregation-induced emission-active supramolecular nanoparticles for gene delivery and bioimaging.
Dual-responsive aggregation-induced emission-active supramolecular nanoparticles for gene delivery and bioimaging.
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DOI：
10.1039/c6cc02794f
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发表时间：
2016-06
影响因子：
4.9
通讯作者：
Ruijiao Dong;Screenath P Ravinathan;Lizhe Xue;Nan Li;YingJian Zhang;Linzhu Zhou;C. Cao;Xinyuan Zhu-Xi
中科院分区：
文献类型：
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作者：
Ruijiao Dong;Screenath P Ravinathan;Lizhe Xue;Nan Li;YingJian Zhang;Linzhu Zhou;C. Cao;Xinyuan Zhu-Xi
报道了双响应聚集诱导发射活性的超分子荧光纳米颗粒，其能够经历独特的形态转变，并结合响应于pH和光刺激的协同光学变化。动态超分子纳米粒子具有良好的生物相容性和有效的质粒DNA缩合能力，进一步实现了高效的体外基因递送和生物成像。
Dual-responsive aggregation-induced emission-active supramolecular fluorescent nanoparticles are reported, which have the ability to undergo a unique morphological transition combining with a cooperative optical variation in response to pH and light stimuli. The dynamic supramolecular nanoparticles show excellent biocompatibility and effective plasmid DNA condensation capability, further achieving efficient in vitro gene delivery and bioimaging.