OBSERVED SLEEP/WAKEFULNESS AND SEVERITY OF DEMENTIA IN AN ALZHEIMERS-DISEASE SPECIAL CARE UNIT
OBSERVED SLEEP/WAKEFULNESS AND SEVERITY OF DEMENTIA IN AN ALZHEIMERS-DISEASE SPECIAL CARE UNIT
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DOI：
10.1093/gerona/50a.6.m303
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发表时间：
1995-11-01
影响因子：
5.1
通讯作者：
KUTNER, N
中科院分区：
文献类型：
--
作者：
BLIWISE, DL;HUGHES, M;KUTNER, N
背景。本研究检验了在特殊护理病房（SCU）治疗阿尔茨海默病（AD）的居民中，行为定义的睡眠障碍与他们痴呆的严重程度有关的假设。在此之前，睡眠实验室的研究报告了在连续几个晚上用多导睡眠描记仪记录睡眠时的这种关系。睡眠的观察性研究并没有显示出这种关系，大概是因为在行为上决定睡眠/清醒状态的不精确性。研究人员对47名平均年龄为80.7±6.5岁的老年痴呆症患者的夜间睡眠数据进行了检查，这些数据基于护理人员在13至18个月期间每两小时进行一次观察。采用Mattis痴呆评定量表（DRS）和Katz日常生活活动量表（ADL）评估痴呆水平和功能能力。结果：数据表明，这些SCU居民在设施中平均有24% +/- 10%的夜晚睡眠受到中度干扰，7% +/- 6%的夜晚睡眠受到严重干扰。痴呆程度越深，睡眠障碍越多；然而，adl的失能、年龄、性别和精神活性药物与这些障碍无关。研究结果表明，通过对睡眠的行为观察，可以发现基于实验室的睡眠测量与痴呆严重程度等变量之间的关系模式，前提是观察的夜晚数量足够大，可以抵消使用这些测量方法所涉及的测量误差。
Background. This study tested the hypothesis that behaviorally defined sleep disturbance among residents in a Special Care Unit (SCU) for Alzheimer's disease (AD) was related to the severity of their dementia. Previously, sleep laboratory studies have reported such relationships when sleep has been recorded polysomnographically over several nights. observational studies of sleep have not shown such relationships, presumably because of the imprecision involved in determining sleep/wake state behaviorally.Methods. Nightly sleep data based on observations made every two hours by nursing staff for a period of 13 to 18 months were examined for 47 AD residents with a mean age of 80.7 +/- 6.5 years. Level of dementia and functional capacity were assessed with the Mattis Dementia Rating Scale (DRS) and the Katz Activities of Daily Living Scale (ADL).Results, Data indicated that these SCU residents experienced a moderately disturbed night of sleep an average of 24% +/- 10% of their nights in the facility and a severely disturbed night of sleep on 7% +/- 6% of those nights. More profound dementia was associated with more sleep disturbance; however, incapacity in ADLs, age, gender, and psychoactive medications were unrelated to such disturbances.Conclusions. The results indicate that patterns of relationships noted between laboratory-based measures of sleep and variables such as severity of dementia can be detected using behavioral observations of sleep, provided that the number of nights of observation are sufficiently large to offset the measurement error involved in their use.