Varicella-zoster virus-specific cell-mediated immunity in subjects with herpes zoster
Varicella-zoster virus-specific cell-mediated immunity in subjects with herpes zoster
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DOI：
10.1016/j.jim.2012.01.003
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发表时间：
2012-03-30
影响因子：
2.2
通讯作者：
Okuno, Toshiomi
中科院分区：
文献类型：
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作者：
Otani, Naruhito;Yamanishi, Kiyofumi;Okuno, Toshiomi
尽管针对水痘-带状疱疹病毒（VZV）的细胞介导免疫（CMI）对预防带状疱疹（HZ）的发病至关重要，但临床医生目前缺乏一种简单的程序来监测CMI。我们最近开发了一种称为ifn - γ释放法的检测方法，并表明这是一种简单可靠的检测vzv特异性CMI的方法。在本研究中，我们采用红外光谱法测量HZ患者的vzv特异性CMI。vzv特异性CMI水平在发病时显著高，但几周后下降。与急性期相比，恢复期CMI vzv特异性抗体滴度升高。因此，这项技术在监测vzv特异性免疫状态方面可能非常有用。(C) 2012 Elsevier B.V.版权所有
Though cell-mediated immunity (CMI) against varicella-zoster virus (VZV) is critical for prevention of the onset of herpes zoster (HZ), clinicians currently lack a simplified procedure to monitor CMI. We have recently developed an assay, called the IFN-gamma release assay, and showed that it is a simple and reliable method to determine VZV-specific CMI. In the present study, we applied an IR assay to measure the VZV-specific CMI of patients with HZ. VZV-specific CMI levels were significantly high at the onset of the disease, but were decreased several weeks later. In contrast, CMI VZV-specific antibody titers increased in convalescent phase compared to those in acute phase. Thus, this technology is likely to be very useful in monitoring ongoing VZV-specific immune status. (C) 2012 Elsevier B.V. All rights reserved.