Use of fMRI to predict recovery from unipolar depression with cognitive behavior therapy
Use of fMRI to predict recovery from unipolar depression with cognitive behavior therapy
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DOI：
10.1176/appi.ajp.163.4.735
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发表时间：
2006-04-01
影响因子：
17.7
通讯作者：
Thase, ME
中科院分区：
文献类型：
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作者：
Siegle, GJ;Carter, CS;Thase, ME
目的：在对照治疗试验中，40%-60%未接受药物治疗的抑郁症患者对认知行为疗法（CBT）有反应。作者研究了预处理神经对情绪刺激的反应是否能解释这种差异。方法：未服药的抑郁症患者（N=14）和未服药的对照组（N=21）在执行一项对持续情绪信息加工敏感的任务时进行功能磁共振成像。之后，抑郁的参与者完成了16次CBT治疗。结果：对情绪刺激持续反应性低的亚属扣带皮层（Brodmann’s area 25）和杏仁核高的参与者在CBT治疗后表现出最强的改善。结论：情绪调节中断的存在，这是CBT的目标，可能是通过这种干预恢复的关键。
Objective: In controlled treatment trials, 40%-60% of unmedicated depressed individuals respond to cognitive behavior therapy ( CBT). The authors examined whether pretreatment neural reactivity to emotional stimuli accounted for this variation.Method: Unmedicated depressed individuals ( N=14) and never depressed comparison subjects ( N=21) underwent fMRI during performance of a task sensitive to sustained emotional information processing. Afterward, depressed participants completed 16 sessions of CBT.Results: Participants whose sustained reactivity to emotional stimuli was low in the subgenual cingulate cortex ( Brodmann's area 25) and high in the amygdala displayed the strongest improvement with CBT.Conclusions: The presence of emotion regulation disruptions, which are targeted in CBT, may be the key to recovery with this intervention.