Assessment of mortality after long-term follow-up of patients with community-acquired pneumonia
Assessment of mortality after long-term follow-up of patients with community-acquired pneumonia
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DOI：
10.1086/379712
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发表时间：
2003-12-15
影响因子：
11.8
通讯作者：
Fine, MJ
中科院分区：
文献类型：
--
作者：
Mortensen, EM;Kapoor, WN;Fine, MJ
尽管研究评估了社区获得性肺炎患者的短期死亡率，但关于影响长期死亡率的预后和风险因素的数据有限。在肺炎患者结局研究小组队列研究的4个研究中心入组的患者中，将入院后存活至少90天的患者的死亡率与年龄匹配的对照受试者进行比较。总的来说，1555例患者中有1419例存活>90天，平均随访期为5. 9年。肺炎患者的长期死亡率明显高于年龄匹配的对照组。与长期死亡率显著相关的因素是年龄（按十年分层）、不复苏状态、营养状况差、胸腔积液、糖皮质激素使用、疗养院住所、高中毕业水平或更低、男性、先前存在的共病和缺乏发热。这项研究表明，肺炎患者的长期死亡率明显高于年龄匹配的对照组，而且长期死亡率在很大程度上不受急性生理紊乱的影响。
Although studies have assessed short- term mortality among patients with community- acquired pneumonia, there is limited data on prognosis and risk factors that affect long- term mortality. The mortality among patients enrolled at 4 sites of the Pneumonia Patient Outcome Research Team cohort study who survived at least 90 days after presentation to the hospital was compared with that among age- matched control subjects. Overall, 1419 of 1555 patients survived for >90 days, with a mean follow- up period of 5.9 years. There was significantly higher long- term mortality among patients with pneumonia than among age- matched controls. Factors significantly associated with long- term mortality were age ( stratified by decade), do- not- resuscitate status, poor nutritional status, pleural effusion, glucocorticoid use, nursing home residence, high school graduation level or less, male sex, preexisting comorbid illnesses, and the lack of feverishness. This study demonstrates that there is significantly higher long- term mortality among patients with pneumonia than among age- matched controls and that long- term mortality largely is not affected by acute physiologic derangements.