Chemical and biological evaluation of unusual sugars, α-aculosides, as novel Michael acceptors.
Chemical and biological evaluation of unusual sugars, α-aculosides, as novel Michael acceptors.
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对不寻常的糖、α-aculosides 作为新型迈克尔受体的化学和生物学评估。
DOI：
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发表时间：
2014
影响因子：
3.2
通讯作者：
K. Toshima
中科院分区：
文献类型：
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作者：
Hiromasa Ikeda;Erika Kaneko;Shunsuke Okuzawa;D. Takahashi;K. Toshima
α-aculoside是一种特殊的糖类，存在于某些抗生素中，具有α，β-不饱和酮结构，是半胱氨酸残基的硫醇功能的新型选择性迈克尔受体。一种香豆素衍生物，具有作为迈克尔受体的α-aculoside，在细胞中作为荧光探针有效且不可逆地操作。此外，α-针叶皂苷对几种癌细胞具有细胞毒活性。
The unusual sugars, α-aculosides, which appear in certain antibiotics and have an α,β-unsaturated ketone structure, were found to be novel and selective Michael acceptors for the thiol function of cysteine residues. A coumarin derivative possessing α-aculoside as a Michael acceptor effectively and irreversibly operated as a fluorescent probe in cells. Furthermore, α-aculosides exhibited cytotoxic activity against several cancer cell lines.
影响因子：
2.9
作者：
LUDUENA, RF;ROACH, MC
通讯作者：
ROACH, MC