Risk of developing major depressive disorder and anxiety disorders among adolescents and adults with atopic dermatitis: A nationwide longitudinal study
Risk of developing major depressive disorder and anxiety disorders among adolescents and adults with atopic dermatitis: A nationwide longitudinal study
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DOI：
10.1016/j.jad.2015.02.025
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发表时间：
2015-06-01
影响因子：
6.6
通讯作者：
Chen, Mu-Hong
中科院分区：
文献类型：
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作者：
Cheng, Chih-Ming;Hsu, Ju-Wei;Chen, Mu-Hong
背景资料：以往的横断面研究表明，特应性皮炎（AD）和抑郁症以及焦虑症之间的共病关联，但时间关系尚未determined.Methods：使用台湾国民健康保险研究数据库，8208 AD患者年龄12岁及以上，没有精神病史和年龄/性别匹配（1：1）的对照组之间的1998年和2008年被纳入我们的研究，并跟踪到2011年底。受试者在随访期间发展为重度抑郁症，任何抑郁障碍和焦虑障碍被确定。结果：调整人口统计学数据和特应性合并症后的考克斯回归分析表明，AD患者发展为重度抑郁症的风险增加（风险比[HR]：6.56，95%置信区间[Cl]：3.64-11.84），任何抑郁症（FIR：544，95% CI：3.99-7.44）和焦虑症（FIR：3.57，95% CI：2.55-4.98）。按年龄组分层，青少年和成人AD患者均易于发展为重度抑郁症（FIR：4.26，95% CI：1.39-13.13; HR：7.56，95% CI：3.75-15.23）、任何抑郁障碍（FIR：4.38，95% CI：2.09-9.18; FIR：5.66，95% CI：2.09-9.18; HR：7.56，95% CI：3.75-15.23）。4.01-7.99）和焦虑症（FIR：5.40，95% CI。2.02-14.39; FIR：3.36，95%，Cl.结论：青少年和成年期的AD增加了以后发展为重度抑郁症、任何抑郁症和焦虑症的风险。AD与抑郁症和焦虑症之间的可能机制有待进一步研究。(C)© 2015 Elsevier B. V.版权所有
Background: Previous cross-sectional studies have suggested a comorbid association between atopic dermatitis (AD) and depressive disorder as well as anxiety disorders, but the temporal relationship was not determined.Methods: Using the Taiwan National Health Insurance Research Database, 8208 AD patients aged 12 and older without psychiatric history and age-/sex-matched (1:1) controls between 1998 and 2008 were enrolled in our study and followed to the end of 2011. Subjects who developed major depression, any depressive disorder, and anxiety disorders during the follow-up were identified.Results: The Cox regression analysis after adjusting for demographic data and atopic comorbidities demonstrated that patients with AD had an elevated risk of developing major depression (hazard ratio [HR]: 6.56, 95% confidence interval [Cl]: 3.64-11.84), any depressive disorder (FIR: 544, 95% Cl: 3.99-7.44), and anxiety disorders (FIR: 3.57, 95% Cl: 2.55-4.98). Stratified by age group, both adolescents and adults with AD were prone to developing major depression (FIR: 4.26, 95% CI: 1.39-13.13; HR: 7.56, 95% Cl, 3.75-15.23), any depressive disorder (FIR: 4.38, 95% Cl: 2.09-9.18; FIR: 5.66, 95% Cl. 4.01-7.99), and anxiety disorders (FIR: 5.40, 95% Cl. 2.02-14.39; FIR: 3.36, 95%, Cl. 2.38-4.80).Conclusions: AD in both adolescence and adulthood increased the risk of developing major depression, any depressive disorder, and anxiety disorders in later life. Further studies would be required to clarify the possible underlying mechanism between AD and depression as well as anxiety disorders. (C) 2015 Elsevier B.V. All rights reserved