Trends in frequency of latent prostate carcinoma in Japan from 1965-1979 to 1982-1986.
Trends in frequency of latent prostate carcinoma in Japan from 1965-1979 to 1982-1986.
复制标题
1965-1979 年至 1982-1986 年日本潜伏性前列腺癌发生率的趋势。
DOI：
10.1093/jnci/80.9.683
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
G. Stemmermann
中科院分区：
文献类型：
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作者：
R. Yatani;T. Shiraishi;K. Nakakuki;Itsuo Kusano;H. Takanari;Takuji Hayashi;G. Stemmermann
通过分析尸检时获得的整个前列腺的连续阶梯切片，我们确定了日本潜伏前列腺肿瘤频率在两个时期（1965-1979 年和 1982-1986 年）的时间变化。两个时期的标本制备和检查方法相同。 1982-1986年的660个样本中发现潜伏性前列腺癌的频率为34.6%，显着高于1965-1979年观察到的576个样本中的22.5%（P小于0.0001）。这一重大发现可归因于潜伏浸润性肿瘤（LIT）频率的增加。然而，非浸润性肿瘤 (LNT) 频率的增加不太显着 (P = .045)。随后，两组标本均根据死者的出生年份进行了合并和重新分析。 LIT 在每个特定年龄类别中的频率逐渐增加。通过形态测量，我们确定平均肿瘤体积由于研究期间较小肿瘤数量的增加而减少。尽管最近获得的样本中潜伏性前列腺癌的发生率和 LIT:LNT 与美国白人相当，但日本的癌症发病率和死亡率仍然较低。显然，日本原住民诱发前列腺癌的最初步骤现在与美国白人相似。与美国和西欧国家相比，日本的临床癌症发病率仍然较低，但我们的研究结果可能预示着有一天这些差异可能会大大减少或不存在。
By analyzing serial step-sections of whole prostate obtained at autopsy, we determined the chronologic change of the frequency of latent prostate tumor in Japan in two periods: 1965-1979 and 1982-1986. Methods of specimen preparation and examination were identical for both periods. The frequency with which latent prostate carcinoma was found in the 660 samples for 1982-1986 was 34.6% and was significantly higher than the 22.5% seen in the 576 observed for 1965-1979 (P less than .0001). This significant finding can be attributed to an increase in the frequency of latent infiltrative tumor (LIT). However, the increase in the frequency of noninfiltrative tumor (LNT) was less significant (P = .045). Both sets of specimens were subsequently combined and reanalyzed according to the year of birth of the decedents. The LIT has progressively increased in frequency in each age-specific category. By morphometry, we determined that the mean tumor volume decreased due to an increase in the number of smaller tumors during the study periods. Although the frequency of latent prostate carcinoma and the LIT:LNT in the samples obtained most recently were comparable to those of U.S. whites, cancer incidence and mortality rates remain lower in Japan. Apparently, the initial step in the induction of prostate carcinoma in indigenous Japanese is now similar to that in U.S. whites. The rates of clinical carcinoma in Japan are still low when compared with those in the United States and countries in Western Europe, but our findings may presage a time when these differences may be greatly reduced or nonexistent.