Effect of polycaprolactone/collagen/hUCS microfiber nerve conduit on facial nerve regeneration
Effect of polycaprolactone/collagen/hUCS microfiber nerve conduit on facial nerve regeneration
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DOI：
10.1016/j.ijbiomac.2016.04.031
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发表时间：
2016-12-01
影响因子：
8.2
通讯作者：
Kim, GeunHyung
中科院分区：
文献类型：
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作者：
Jang, Chul Ho;Lee, Hyeongjin;Kim, GeunHyung
神经导管已被用来桥接神经间隙，而不会出现与神经移植相关的供区并发症。为了制造人工神经导管，人们使用了各种生物、合成和天然材料。在这项研究中，我们提出了一种新的纤维神经导管，由添加了胶原和人脐血清的PCL微纤维组成。与纯PCL和PCL/胶原纤维导管相比，所提出的基于PCL的神经导管在体内外的生物活性显著高于PCL和PCL/胶原纤维导管。基于这些结果，我们认为PCL/胶原/HUC纤维导管为面神经(FN)的再生提供了更有利的微环境，对FN横断损伤的再生具有比自体移植更大的治疗潜力。(C)2016爱思唯尔B.V.保留所有权利。
Nerve conduits have been used to bridge nerve gaps without the donor site morbidity associated with nerve grafting. To fabricate artificial nerve conduits, various biological, synthetic, and natural materials have been applied. In this study, we suggest a new fibrous nerve conduit consisting of PCL microfibers supplemented with collagen and human umbilical cord serum (hUCS). The proposed PCL-based nerve conduit exhibited significantly higher bioactivities in vitro and in vivo, compared to pure PCL and PCL/collagen fibrous conduits. Based on these results, we believe that the PCL/collagen/hUCS fibrous conduit provides more favorable micro-environmental conditions for facial nerve (FN) regeneration and has more therapeutic potential for the regeneration of FN transectional damage than the autograft technique. (C) 2016 Elsevier B.V. All rights reserved.