Exposure to maternal pre- and postnatal depression and anxiety symptoms: Risk for major depression, anxiety disorders, and conduct disorder in adolescent offspring
Exposure to maternal pre- and postnatal depression and anxiety symptoms: Risk for major depression, anxiety disorders, and conduct disorder in adolescent offspring
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DOI：
10.1017/s0954579413000369
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发表时间：
2013-11-01
影响因子：
3.3
通讯作者：
Day, Nancy L.
中科院分区：
文献类型：
--
作者：
Glasheen, Cristie;Richardson, Gale A.;Day, Nancy L.
这项研究评估了母亲产前或产后抑郁或焦虑症状的暴露是否可以预测青少年后代的精神病理学。使用生长混合模型来确定从产前诊所选出的 577 名社会经济地位较低的女性的产前和产后抑郁和焦虑症状的轨迹。 Logistic回归模型表明，母亲产前和产后的抑郁轨迹暴露与后代的重度抑郁、焦虑或品行障碍无关，但暴露于高度抑郁轨迹与男性较低的焦虑症状相关。产前和产后处于中度和高度焦虑状态与后代品行障碍的风险相关。暴露于中度和高度产前和产后焦虑的男性后代比暴露水平较低的男性后代出现品行障碍的几率更高。与暴露程度较低的女性相比，处于中度或高度产前和产后焦虑的女性符合品行障碍标准的可能性较小。据我们所知，这是第一项研究产前和产后焦虑轨迹对后代品行障碍风险影响的研究。这些结果为研究行为障碍的病因学和新的干预目标提供了新的方向。
This study evaluated whether exposure to maternal pre- or postnatal depression or anxiety symptoms predicted psychopathology in adolescent offspring. Growth mixture modeling was used to identify trajectories of pre- and postnatal depression and anxiety symptoms in 577 women of low socioeconomic status selected from a prenatal clinic. Logistic regression models indicated that maternal pre- and postnatal depression trajectory exposure was not associated with offspring major depression, anxiety, or conduct disorder, but exposure to the high depression trajectory was associated with lower anxiety symptoms in males. Exposure to medium and high pre- and postnatal anxiety was associated with the risk of conduct disorder among offspring. Male offspring exposed to medium and high pre- and postnatal anxiety had higher odds of conduct disorder than did males with low exposure levels. Females exposed to medium or high pre- and postnatal anxiety were less likely to meet conduct disorder criteria than were females with lower exposure. To the best of our knowledge, this is the first study to examine the effect of pre- and postnatal anxiety trajectories on the risk of conduct disorder in offspring. These results suggest new directions for investigating the etiology of conduct disorder with a novel target for intervention.