Avian influenza A virus H5N1 causes autophagy-mediated cell death through suppression of mTOR signaling
Avian influenza A virus H5N1 causes autophagy-mediated cell death through suppression of mTOR signaling
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DOI：
10.1016/j.jgg.2011.10.002
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发表时间：
2011-11-01
影响因子：
5.9
通讯作者：
Zhang, Hongbing
中科院分区：
文献类型：
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作者：
Ma, Jianhui;Sun, Qian;Zhang, Hongbing
在少数跨越物种屏障感染人类的禽流感病毒中，高致病性甲型H5N1流感病毒株已夺走了一半以上受感染患者的生命。由于H5N1感染致肺损伤的机制尚不清楚，急性呼吸窘迫综合征(ARDS)是造成患者死亡的主要原因。在这里，我们提出了H5N1通过抑制mTOR信号导致自噬细胞死亡的事实。通过去除自噬基因Beclin1或自噬抑制剂3-甲基腺嘌呤(3-MA)抑制自噬，可显著减少H5N1介导的细胞死亡。我们认为自噬细胞死亡可能有助于H5N1流感患者ARDS的发展，因此抑制自噬可能成为治疗H5N1感染的一种新策略。
Of the few avian influenza viruses that have crossed the species barrier to infect humans, the highly pathogenic influenza A (H5N1) strain has claimed the lives of more than half of the infected patients. With largely unknown mechanism of lung injury by H5N1 infection, acute respiratory distress syndrome (ARDS) is the major cause of death among the victims. Here we present the fact that H5N1 caused autophagic cell death through suppression of mTOR signaling. Inhibition of autophagy, either by depletion of autophagy gene Beclin1 or by autophagy inhibitor 3-methyladenine (3-MA), significantly reduced H5N1 mediated cell death. We suggest that autophagic cell death may contribute to the development of ARDS in H5N1 influenza patients and inhibition of autophagy could therefore become a novel strategy for the treatment of H5N1 infection.