Volumes of the components of the hippocampus in the aging F344 rat.
Volumes of the components of the hippocampus in the aging F344 rat.
复制标题
衰老 F344 大鼠海马各成分的体积。
DOI：
10.1002/cne.902660213
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
West,MJ
中科院分区：
文献类型：
--
作者：
Coleman,PD;Flood,DG;West,MJ
最近关于齿状回和海马中的细胞、突触和其他结构与年龄的关系的大部分数据都是堆积密度或体积分数数据。为了估计细胞、突触、血管等的总数、体积或表面积作为年龄的函数，必须知道齿状回和海马的子区域的总体积。已在 24 只 4 至 37 个月大的 F344 大鼠中测定了这些分区的体积，通过 Timm 染色进行可视化。各种结构的体积显示出与年龄相关的增加，这对于齿状回分子层的穿通路径区域、以及总分子层、门、下区域和总苔藓纤维系统具有统计显着性。如果排除4个月龄组，只有苔藓纤维区的体积与齿状分子层的穿孔路径区的体积之比随着年龄显着增加。我们的一般发现是，在 12 至 37 个月之间，海马区域的分区缺乏体积重组，这表明，假设采样区域具有可比性，对大多数这些区域的结构堆积密度的研究可以被认为在不同年龄之间具有可比性。
Much of the recent data on cells, synapses, and other structures in the dentate gyrus and hippocampus as a function of age are packing density or volume fraction data. In order to estimate total numbers, volumes, or surface areas of cells, synapses, vessels, etc., as a function of age, the total volumes of the subregions of the dentate gyrus and hippocampus must be known. The volumes of these subregions, visualized with the Timm stain, have been determined in 24 F344 rats from 4 to 37 months of age. Volumes of the various structures showed age‐related increases which were statistically significant for the perforant path zone of the dentate gyrus molecular layer, as well as the total molecular layer, the hilus, and regio inferior and total mossy fiber systems. If the 4‐month age group is eliminated from consideration, only the ratio of the volume of the mossy fiber zones to the volume of the perforant path zones of the dentate molecular layer increases significantly with age. Our general finding of lack of volumetric reorganization of the subdivisions of the hippocampal region between 12 and 37 months suggests that studies of the packing densities of structures in most of these zones may be considered comparable across ages, assuming comparability of sampling regions.