The Multicomponent Day-Care Program Prevents Volume Reduction in a Memory-Related Brain Area in Patients with Mild Cognitive Impairment
The Multicomponent Day-Care Program Prevents Volume Reduction in a Memory-Related Brain Area in Patients with Mild Cognitive Impairment
复制标题
DOI：
10.1159/000522654
复制
发表时间：
2022-03
影响因子：
2.4
通讯作者：
Youshun Boku;Miho Ota;M. Nemoto;Y. Numata;Aya Kitabatake;Takumi Takahashi;K. Nemoto;Masashi Tamura;Aya Sekine;Masayuki Ide;Y. Kaneda;T. Arai
中科院分区：
文献类型：
--
作者：
Youshun Boku;Miho Ota;M. Nemoto;Y. Numata;Aya Kitabatake;Takumi Takahashi;K. Nemoto;Masashi Tamura;Aya Sekine;Masayuki Ide;Y. Kaneda;T. Arai
前言：轻度认知障碍(MCI)被认为是预防进展为痴呆的干预措施的重要时期。对MCI的非药物干预包括运动训练、认知干预和音乐治疗。它们在改善认知功能方面发挥着重要作用，但它们对MCI患者大脑可塑性的影响在很大程度上是未知的。我们调查了筑波大学医院提供的多组分日托计划对MCI患者纵向脑体积变化的影响。方法：14例MCI患者参加了多组分日托计划，并在参与期间进行了两次全脑磁共振成像(MRI)。我们根据出勤率将他们分为两组，并对整个大脑皮层的纵向体积变化进行组间分析。用Freesurfer 6.0.0软件计算患者MRI所得的局部脑体积。结果：神经影像分析显示，与低出勤组相比，高出勤组的左侧嘴前扣带回皮质体积明显保留。结论：我们的结果表明，持续参与多组分的日托计划有助于防止MCI患者记忆相关脑区的体积减少。
Introduction: Mild cognitive impairment (MCI) is considered an important period for interventions to prevent progression to dementia. Nonpharmacological interventions for MCI include exercise training, cognitive intervention, and music therapy. These play an important role in improving cognitive function, but their effects on brain plasticity in individuals with MCI are largely unknown. We investigated the effects of a multicomponent day-care program provided by the University of Tsukuba Hospital on the longitudinal brain volume changes in MCI patients. Methods: MCI patients who participated in the multicomponent day-care program and underwent whole-brain magnetic resonance imaging (MRI) twice during their participation (n = 14), were included. We divided them into two groups according to their attendance rate and conducted a between-group analysis of longitudinal volume changes in the whole cerebral cortex. Regional brain volumes derived from the patients’ MRI were calculated with Freesurfer 6.0.0. Results: The neuroimaging analysis demonstrated that the left rostral anterior cingulate cortex volume was significantly preserved in the high-attendance group compared to that of the low-attendance group. Conclusion: Our results suggest that continuous participation in a multicomponent day-care program could help prevent a volume reduction in memory-related brain areas in patients with MCI.