En Route to (S)-Selective Chemoenzymatic Dynamic Kinetic Resolution of Aliphatic Amines. One-Pot KR/Racemization/KR Sequence Leading to (S)-Amides
En Route to (S)-Selective Chemoenzymatic Dynamic Kinetic Resolution of Aliphatic Amines. One-Pot KR/Racemization/KR Sequence Leading to (S)-Amides
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DOI：
10.1021/jo900074w
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发表时间：
2009-04-03
影响因子：
3.6
通讯作者：
Gil, Gerard
中科院分区：
文献类型：
--
作者：
El Blidi, Lahssen;Nechab, Malek;Gil, Gerard
一锅顺序反应，包括自由基外消旋化和酶解，提供了从外消旋胺获得(S)-酰胺的途径，ee和产率分别为78 - 94%和58 - 80%。
A one-pot sequential process, involving a radical racemization and an enzymatic resolution, provides access to (S)-amides, from racemic amines, with ee and yields ranging from 78 to 94% and 58 to 80%, respectively.