Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study
Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study
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DOI：
10.1002/ijc.23319
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发表时间：
2008-05-15
影响因子：
6.4
通讯作者：
Abnet, Christian C.
中科院分区：
文献类型：
--
作者：
Freedman, Neal D.;Park, Yikyung;Abnet, Christian C.
鳞状头颈癌包括口腔癌、咽癌和喉癌，是全球第六大癌症死亡原因，每年导致超过 35 万人死亡。摄入水果和蔬菜可以预防头颈癌的发病，尽管很少有前瞻性研究检验这种关联。我们使用针对潜在混杂因素进行调整的 Cox 比例风险模型，对 NIH-AARP 饮食与健康队列的 490,802 名美国参与者调查了这种关系。在 1995/1996 至 2000 年的 2,193,751 人年随访中，787 名参与者被诊断患有头颈癌。我们发现水果和蔬菜的总摄入量与头颈癌风险之间呈负相关（每份/天/1,000 卡路里，风险比，95% 置信区间：0.94、0.89-0.99）。在针对水果和蔬菜摄入量相互调整的模型中，蔬菜（第五与第一五分位数：0.65、0.50-0.85）的相关性比水果（第五与第一五分位数：0.87、0.68-1.11）更强。当进一步细分为植物类群时，最高三分位数为豆科（干豆、四季豆和豌豆，0.80、0.67-0.96）、蔷薇科（苹果、桃、油桃、李子、梨和草莓，0.60、0.49-0.73）、茄科（辣椒和西红柿，0.82） 0.69-0.98）和伞形科植物（胡萝卜，0.73、0.60-0.89）降低了头颈癌的风险，但其他 9 个植物组没有发现显着关联。这项大型前瞻性观察研究的结果与之前的病例对照研究一致，并支持水果和蔬菜总摄入量与头颈癌风险降低相关的假设。 (C) 2007 Wiley-Liss, Inc.
Squamous head and neck cancers include cancers of the oral cavity, pharynx and larynx are the sixth leading cause of cancer mortality worldwide, resulting in more than 350,000 deaths annually. Intake of fruit and vegetables may protect against head and neck cancer incidence, although few prospective studies have examined this association. We investigated this relation in 490,802 United States participants of the NIH-AARP Diet and Health cohort using Cox proportional hazard models adjusted for potential confounders. During 2,193,751 person years of follow-up from 1995/1996-2000, 787 participants were diagnosed with head and neck cancer. We found an inverse association between total fruit and vegetable intake and head and neck cancer risk (per serving/day/1,000 calories, Hazard Ratio, 95% Confidence interval: 0.94, 0.89-0.99). In models mutually adjusted for fruit and vegetable intake, the association was stronger for vegetables (fifth vs. first quintile: 0.65, 0.50-0.85) than for fruits (fifth vs. first quintile: 0.87, 0.68-1.11). When further subclassified into botanical groups, those in the highest tertile of leguminosae (dried beans, string beans and peas, 0.80, 0.67-0.96), rosaceae (apples, peach, nectarines, plums, pears and strawberries, 0.60, 0.49-0.73), solanaceae (peppers and tomatoes, 0.82, 0.69-0.98) and umbelliferae (carrots, 0.73, 0.60-0.89) had decreased risk of head and neck cancer, but no significant associations were seen for 9 other botanical groups. Results from this large prospective observational study are consistent with previous case-control studies and support the hypothesis that total fruit and vegetable intake is associated with reduced risk of head and neck cancer. (C) 2007 Wiley-Liss, Inc.