Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows.
Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows.
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DOI：
10.1038/s41598-021-87052-x
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发表时间：
2021-04-12
影响因子：
4.6
通讯作者：
Ogawa Y
中科院分区：
文献类型：
--
作者：
Muta K;Ihara E;Hamada S;Ikeda H;Wada M;Hata Y;Bai X;Nishihara Y;Tanaka Y;Ogino H;Ogawa Y
下食道括约肌(LES)在吞咽前的准备调节反应是湿吞咽时LES松弛的机制之一，然而LES调节在人体中的生理和/或病理作用仍有待确定。为了解决这个问题，我们对38名正常高分辨率测压(HRM)患者和23名特发性食管胃出口梗阻(EGJOO)患者进行了一项前瞻性观察研究，以评估干燥和潮湿的燕子。提出了LES调节测量在评估LES调节反应中的实际应用。尽管在干燕子和湿燕子中都观察到了吞咽诱导的LES松弛，但仅在湿燕子中观察到LES调节(6.4，3.1-11.1 mm Hg)。特发性高血压组LES调节受损(0.6， − 0.6~6 mm Hg)，其LES调节测量值(36.8，2 9.5~44.3 mm Hg)显著高于正常组(2 3.8，18~2 8.6 mm Hg)。湿性吞咽时的LES松弛可通过LES调节与吞咽诱导的LES松弛相结合来实现。LES调节受损是特发性EGJOO的特征。除IRP值外，LES调节测量还可用于临床评估LES松弛功能。
The preparatory accommodation response of lower esophageal sphincter (LES) before swallowing is one of the mechanisms involved in LES relaxation during wet swallows, however, the physiological and/or pathological roles of LES accommodation remain to be determined in humans. To address this problem, we conducted a prospective observational study of 38 patients with normal high-resolution manometry (HRM) and 23 patients with idiopathic esophagogastric junction outflow obstruction (EGJOO) to assess dry and wet swallows. The LES accommodation measurement was proposed for practical use in evaluating the LES accommodation response. Although swallow-induced LES relaxation was observed in both dry and wet swallows, LES accommodation (6.4, 3.1–11.1 mmHg) was only observed in wet swallows. The extent of LES accommodation was impaired in idiopathic EGJOO (0.6, − 0.6–6 mmHg), and the LES accommodation measurement of patients with idiopathic EGJOO (36.8, 29.5–44.3 mmHg) was significantly higher in comparison to those with normal HRM (23.8, 18–28.6 mmHg). Successful LES relaxation in wet swallowing can be achieved by LES accommodation in combination with swallow-induced LES relaxation. Impaired LES accommodation is characteristic of idiopathic EGJOO. In addition to the IRP value, the LES accommodation measurement may be useful for evaluating the LES relaxation function in clinical practice.
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影响因子：
3.5
作者：
Kusunoki, H.;Haruma, K.;Tack, J.
通讯作者：
Tack, J.
DOI：
10.1152/ajpgi.00301.2002
发表时间：
2003-02-01
影响因子：
4.5
作者：
Pouderoux, P;Verdier, E;Kahrilas, PJ
通讯作者：
Kahrilas, PJ
DOI：
10.1007/s00464-016-5217-y
发表时间：
2017-05-01
影响因子：
3.1
作者：
Crespin, Oscar M.;Liu, Louis W. C.;Okrainec, Allan
通讯作者：
Okrainec, Allan
影响因子：
3.2
作者：
Muta, Kazumasa;Ihara, Eikichi;Nakamura, Kazuhiko
通讯作者：
Nakamura, Kazuhiko
影响因子：
9.8
作者：
Ratuapli, Shiva K.;Crowell, Michael D.;Murray, Joseph A.
通讯作者：
Murray, Joseph A.