Location Matters: Profiling Diffuse Type Gastric Cancer At the Single-Cell Level.
Location Matters: Profiling Diffuse Type Gastric Cancer At the Single-Cell Level.
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DOI：
10.1158/1078-0432.ccr-21-2935
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发表时间：
2021-12-01
期刊：
影响因子：
--
通讯作者：
Brekken RA
中科院分区：
文献类型：
--
作者：
Huang H;Brekken RA
原发性弥漫型胃癌患者的空间单细胞转录组学揭示了基于位置的不同癌症和基质细胞差异。CCL2在深部肿瘤区域的基质细胞的表达被强调为潜在地驱动免疫抑制微环境和增强（直接或间接）肿瘤细胞的侵袭能力。
Spatial single cell transcriptomics of primary patient diffuse type gastric cancer reveals distinct cancer and stromal cell differences based on location. Expression of CCL2 by stromal cells in deep tumor regions is highlighted as potentially driving the immunosuppressive microenvironment and enhancing (directly or indirectly) the invasive capacity of tumor cells.