DIABETES IN PREGNANCY IN ZUNI INDIAN WOMEN - PREVALENCE AND SUBSEQUENT DEVELOPMENT OF CLINICAL DIABETES AFTER GESTATIONAL DIABETES
DIABETES IN PREGNANCY IN ZUNI INDIAN WOMEN - PREVALENCE AND SUBSEQUENT DEVELOPMENT OF CLINICAL DIABETES AFTER GESTATIONAL DIABETES
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DOI：
10.2337/diacare.16.9.1231
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发表时间：
1993-09-01
期刊：
影响因子：
16.2
通讯作者：
GOHDES, D
中科院分区：
文献类型：
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作者：
BENJAMIN, E;WINTERS, D;GOHDES, D
目的-以确定妊娠糖尿病的患病率在祖尼印度妇女和随后的糖尿病发病率之间的祖尼妇女GDM.RESEARCH设计和方法-一项回顾性分析809分娩超过4年的时间内祖尼印度妇女进行了确定的患病率GDM和糖尿病提前怀孕。对47名患有GDM的纯种祖尼印度妇女和47名对照受试者进行了一项前瞻性病例对照研究，以确定首次诊断为GDM的妇女向临床糖尿病的进展。在规定的8年期间分娩的GDM病例。对照组的祖尼妇女在相同的时间段内分娩，但在1小时葡萄糖筛查试验中血糖值< 7.8 mM。GDM病例和对照组在年龄、体重指数、妊娠次数和随访时间方面相匹配。所有的妇女进行了重新评估糖尿病长达9年后，指数pregnancy.RESULTS -1987年至1990年，116例GDM和8例预先存在的糖尿病被确定，产妇糖尿病的患病率为15.3%。在随访的时候，14 47（30%）GDM的妇女已经发展成糖尿病后，平均4.8年，而只有3 47（6%）从对照组的平均5.5年follow-up.CONCLUSIONS - GDM是普遍存在的祖尼印度人，并与糖尿病的风险增加。GDM后的葡萄糖耐量在美洲原住民中可能比其他人群更快恶化。
OBJECTIVE - To determine the prevalence of gestational diabetes mellitus in Zuni Indian women and the subsequent rate of diabetes among Zuni women with GDM.RESEARCH DESIGN AND METHODS - A retrospective analysis of 809 deliveries over a 4-yr period among Zuni Indian women was conducted to determine the prevalence of GDM and diabetes antedating pregnancy. A prospective case-control study of 47 full-blooded Zuni Indian women with GDM and 47 control subjects was performed to determine the progression to clinical diabetes in women with a first-time diagnosis of GDM. Cases with GDM delivered during a defined 8-yr period. The control group of Zuni women delivered during the same time period but had plasma glucose values < 7.8 mM on the 1-h glucose screening test. Cases with GDM and control subjects were matched for age, body mass index, gravidity, and length of follow-up. All women were re-evaluated for diabetes up to 9 yr after the index pregnancy.RESULTS - Between 1987-1990, 116 cases of GDM and 8 cases of pre-existing diabetes were identified, giving a prevalence of maternal diabetes in pregnancy of 15.3%. At the time of follow-up, 14 of 47 (30%) women with GDM had developed diabetes after a mean of 4.8 yr compared with only 3 of 47 (6%) from the control group with an average of 5.5 yr follow-up.CONCLUSIONS - GDM is prevalent among Zuni Indians and is associated with an increased risk of diabetes. Glucose tolerance after GDM may deteriorate at a greater rate in Native Americans than in other populations.