Corn stover semi-mechanistic enzymatic hydrolysis model with tight parameter confidence intervals for model-based process design and optimization
Corn stover semi-mechanistic enzymatic hydrolysis model with tight parameter confidence intervals for model-based process design and optimization
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DOI：
10.1016/j.biortech.2014.11.062
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发表时间：
2015-02-01
影响因子：
11.4
通讯作者：
Aroca, German
中科院分区：
文献类型：
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作者：
Scott, Felipe;Li, Muyang;Aroca, German
与模型中参数估计值相关的不确定性是决策者和模型用户的关键信息。然而，通常不会报告此信息，或者置信区间太大而无用。这项工作提出了一种用于稀酸预处理玉米秸秆酶促糖化的半机械模型，该模型是对现有模型的修改，提供了对一组实验数据的统计学上显着改进的拟合，其中包括不同的初始固体负载（10-25％w/w）以及预处理液和洗涤固体的使用（补充或不补充关键抑制剂）。确定了 17 个参数中的 8 个参数的子集，显示出足够严格的置信区间，可用于不确定性传播和模型分析，无需通过专家判断进行区间截断。 (C) 2014 Elsevier Ltd. 保留所有权利。
Uncertainty associated to the estimated values of the parameters in a model is a key piece of information for decision makers and model users. However, this information is typically not reported or the confidence intervals are too large to be useful. A semi-mechanistic model for the enzymatic saccharification of dilute acid pretreated corn stover is proposed in this work, the model is a modification of an existing one providing a statistically significant improved fit towards a set of experimental data that includes varying initial solid loadings (10-25% w/w) and the use of the pretreatment liquor and washed solids with or without supplementation of key inhibitors. A subset of 8 out of 17 parameters was identified, showing sufficiently tight confidence intervals to be used in uncertainty propagation and model analysis, without requiring interval truncation via expert judgment. (C) 2014 Elsevier Ltd. All rights reserved.