Dynamic processes shape spatiotemporal properties of retinal waves
Dynamic processes shape spatiotemporal properties of retinal waves
复制标题
DOI：
10.1016/s0896-6273(00)80940-x
复制
发表时间：
1997-08-01
期刊：
影响因子：
16.2
通讯作者：
Shatz, CJ
中科院分区：
文献类型：
--
作者：
Feller, MB;Butts, DA;Shatz, CJ
在发育中的哺乳动物视网膜，自发波的动作电位存在于神经节细胞层前几周的视觉。这些波是由无突细胞和视网膜神经节细胞的突触连接网络产生的，并表现出复杂的时空模式，其特征是共激活的移位域。在这里，我们提出了一个新的动力学模型，由两个耦合的细胞群组成，定量地再现了实验观察到的区域大小、波间间隔和波前速度剖面。模型和实验共同表明，视网膜波产生的高度相关的活动可以用细胞随机自发激活和局部视网膜活动的过去历史相结合来解释。
In the developing mammalian retina, spontaneous waves of action potentials are present in the ganglion cell layer weeks before vision. These waves are known to be generated by a synaptically connected network of amacrine cells and retinal ganglion cells, and exhibit complex spatiotemporal patterns, characterized by shifting domains of coactivation. Here, we present a novel dynamical model consisting of two coupled populations of cells that quantitatively reproduces the experimentally observed domain sizes, interwave intervals, and wavefront velocity profiles. Model and experiment together show that the highly correlated activity generated by retinal waves can be explained by a combination of random spontaneous activation of cells and the past history of local retinal activity.