Integrated pathway-genome databases and their role in drug discovery
Integrated pathway-genome databases and their role in drug discovery
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DOI：
10.1016/s0167-7799(99)01316-5
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发表时间：
1999-07-01
影响因子：
17.3
通讯作者：
Wagg, J
中科院分区：
文献类型：
--
作者：
Karp, PP;Krummenacker, M;Wagg, J
集成的途径基因组数据库描述了生物体的基因和基因组，以及其预测的途径，反应，酶和代谢产物。结合可视化和分析软件，这些数据库提供了一个框架，以提高对微生物生理学的理解和抗菌药物的发现。我们描述了一些医学相关微生物的基因组的基于路径的分析和一种新的软件工具，该软件工具在显示微生物的整个代谢网络的图上可视化基因表达数据。
Integrated pathway-genome databases describe the genes and genome of an organism, as well as its predicted pathways, reactions, enzymes and metabolites. In conjunction with visualization and analysis software, these databases provide a framework for improved understanding of microbial physiology and for antimicrobial drug discovery. We describe pathway-based analyses of the genomes of a number of medically relevant microorganisms and a novel software tool that visualizes gene-expression data on a diagram showing the whole metabolic network of the microorganism.