Suppressing surface reconstruction of superhydrophobic PDMS using a superhydrophilic zwitterionic polymer.
Suppressing surface reconstruction of superhydrophobic PDMS using a superhydrophilic zwitterionic polymer.
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DOI：
10.1021/bm300399s
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发表时间：
2012-05-14
影响因子：
6.2
通讯作者：
Jiang S
中科院分区：
文献类型：
--
作者：
Keefe AJ;Brault ND;Jiang S
聚二甲基硅氧烷 (PDMS) 因其成本低、易于制造、高耐用性和灵活性、透氧性和自修复特性而广泛用于生物医学应用。然而，PDMS 有一些明显的缺点。由于其超疏水特性，PDMS 在与生物样品一起使用时可承受高水平的非特异性蛋白质污染。不幸的是，由于 PDMS 的玻璃化转变温度较低，传统的表面改性方法对其不起作用。这种现象多年来一直被称为“疏水再生”。出于同样的原因，将功能带到 PDMS 表面上也非常困难。在此，我们展示了超亲水性两性离子材料聚（羧基甜菜碱甲基丙烯酸酯）（pCBMA）如何由于 pCBMA 和 PDMS 之间疏水性的鲜明对比而提供具有长期稳定性的高度稳定的涂层。这种材料能够抑制复杂介质中的非特异性蛋白质吸附，并对诊断等应用中所需的所需生物分子进行功能化，而不会牺牲其防污特性。
Poly(dimethyl siloxane) (PDMS) is extensively used for biomedical applications due to its low cost, ease of fabrication, high durability and flexibility, oxygen permeability, and self-healing properties. PDMS, however, has some significant drawbacks. PDMS endures unacceptably high levels of non-specific protein fouling when used with biological samples due to its superhydrophobic characteristics. Unfortunately, conventional surface modification methods do not work for PDMS due to its low glass transition temperature. This phenomenon has been well-known for years as “hydrophobic regeneration”. For the same reason, it is also very difficult to bring functionalities onto PDMS surfaces. Herein, we demonstrate how a superhydrophilic zwitterionic material, poly(carboxybetaine methacrylate) (pCBMA), can provide a highly stable coating with long term stabilty due to the sharp contrast in hydrophobicity between pCBMA and PDMS. This material is able to suppress nonspecific protein adsorption in complex media and functionalize desired biomolecules needed in applications, such as diagnostics, without sacrificing its nonfouling characteristics.