The Clinical Significance of Small Sharp Spikes in the Electroencephalogram
The Clinical Significance of Small Sharp Spikes in the Electroencephalogram
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脑电图中小尖峰的临床意义
DOI：
10.1177/155005947500600305
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
E. Niedermeyer
中科院分区：
文献类型：
--
作者：
Y. Koshino;E. Niedermeyer
脑电图上不明显的尖峰模式的描绘（“小尖峰”，= SSS）1'2 仅引起了很少且有些争议的进一步报告。 Gibbs 和 Gibbs2 给出了“癫痫异常”的属性，另一方面，他们强调 SSS 模式的症状特征不明显，并且在假定的正常成人对照受试者中患病率相当高（在 40 至 49 岁的年龄范围内达到 7.9%）。 Reiher 和 Klass3 以及 Reiher 等人 01.4 也研究了这种放电的临床意义，他们提出了伴有癫痫发作的颅内肿瘤病例以及脑电图上以 SSS 为特征的其他一些疾病的病例；这些作者认为这种模式没有病理意义，也没有定位价值。在深度脑电图研究中对 SSS 的一个非常有趣的观察表明这些低电压尖峰的发生器区域很大。 Small6 研究了精神病人群中 SSS 的发生情况，并强调了该模式在情感障碍中的重要性；最近，Small 等人 01.7 怀疑 SSS 具有遗传特征，“在某种程度上与躁狂抑郁症的家族传播有关”。当人们认为一组研究人员强调 112 SSS 放电的癫痫特征，第二组 17 强调其与躁狂抑郁症遗传学的关系，而第三组 3-5 则强调负面特征（例如缺乏病理意义）而不最小化与癫痫病症的关系时，对先前工作的简短回顾一定会非常令人困惑。这种不同的观点不一定是不可调和的，但肯定会激励我们重新审视 SSS 模式的电临床相关性。
The delineation of an inconspicuous spike pattern in the electroencephalogram ("Small sharp spikes", = SSS)1'2 has prompted only scanty and somewhat controversial further reports. The attribute of an "epileptic abnormality" was given by Gibbs and Gibbs2 who, on the other hand, stressed the nondescript symptom profile of the SSS pattern and a rather high prevalence in presumed normal adult control subjects (reaching 7.9% in the age range from 40 to 49 years). The clinical significance of this discharge was also studied by Reiher and Klass3 as well by Reiher et 01.4 who presented cases of intracranial tumors with epileptic seizures and some other disorders featuring SSS in the EEG; these authors ascribe no pathological significance and no localizing value to this pattern. A very interesting observation of SSS in a depth EEG study5 indicates the large extent of the generator area of these low voltage spikes. Small6 studied the occurrence of SSS in a psychiatric population and emphasized the significance of the pattern in affective disorders; more recently, Small et 01.7 suspected an inherited characteristic of SSS, "related in some way to the familial transmission of manic-depressive disease". This brief review of previous work must be quite confusing when one considers that one group of investigators emphasizes112 the epileptic character of the SSS discharge, a second groupsi7 stresses its relationship to the genetics of manic-depressive illness while a third group3-5 places the emphasis on negative features (such as lack of pathological significance) without minimizing the relationship to epileptic conditions. Such divergent views are not necessarily irreconcilable but certainly constitute an incentive to take a fresh look at the electroclinical correlations of the SSS pattern.