Synthesis of 2,3-Ring Fused Pyrroles via Cu-Catalyzed 5-exo-dig Annulation of Alkyne-Tethered Enaminones
Synthesis of 2,3-Ring Fused Pyrroles via Cu-Catalyzed 5-exo-dig Annulation of Alkyne-Tethered Enaminones
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通过铜催化炔系烯胺酮的 5-exo-dig 环化合成 2,3-环稠合吡咯
DOI：
10.1021/acs.joc.9b02672
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发表时间：
2019
影响因子：
3.6
通讯作者：
Liu Wen-Bo
中科院分区：
文献类型：
--
作者：
Li Weishuang;Usman Muhammad;Wu Lin-Yang;Liu Wen-Bo
本文报道了铜催化的炔基烯胺酮成环反应合成2，3-环稠吡咯的方法。5-exo-dig环化/烯烃迁移反应以59-99%的产率提供了16个实例的多取代吡咯。该方法的特点是原料易得，反应条件温和，无配体，铜催化剂廉价。原子经济转化提供了一个简单的途径来合成各种有用的吡咯及其衍生物。
A copper-catalyzed annulation of alkyne-tethered enaminones for the synthesis of 2,3-ring fused pyrroles is reported. The 5-exo-dig cyclization/olefin migration reaction delivers the multisubstituted pyrroles in 59–99% yields with 16 examples. This strategy features easily available starting materials, mild reaction conditions, and a cheap ligand-free copper catalyst. The atom-economic transformation provides a simple access to a variety of synthetic useful pyrroles and their derivatives.