CADHERIN CELL-ADHESION RECEPTORS AS A MORPHOGENETIC REGULATOR
CADHERIN CELL-ADHESION RECEPTORS AS A MORPHOGENETIC REGULATOR
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DOI：
10.1126/science.2006419
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发表时间：
1991-03-22
期刊：
影响因子：
56.9
通讯作者：
TAKEICHI, M
中科院分区：
文献类型：
--
作者：
TAKEICHI, M
钙粘蛋白是一个细胞粘附受体家族，对脊椎动物细胞的相互关联至关重要。 通过它们的嗜同性结合相互作用，钙粘蛋白在细胞分选机制中发挥作用，赋予细胞粘附特异性。 钙粘蛋白的调节表达也控制细胞极性和组织形态。 因此，钙粘蛋白被认为是形态发生的重要调节因子。 此外，病理检查表明，钙粘蛋白表达下调与肿瘤细胞的侵袭性。
Cadherins are a family of cell adhesion receptors that are crucial for the mutual association of vertebrate cells. Through their homophilic binding interactions, cadherins play a role in cell-sorting mechanisms, conferring adhesion specificities on cells. The regulated expression of cadherins also controls cell polarity and tissue morphology. Cadherins are thus considered to be important regulators of morphogenesis. Moreover, pathological examinations suggest that the down-regulation of cadherin expression is associated with the invasiveness of tumor cells.