Exercise-induced suppression of acylated ghrelin in humans
Exercise-induced suppression of acylated ghrelin in humans
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DOI：
10.1152/japplphysiol.00759.2006
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发表时间：
2007-06-01
影响因子：
3.3
通讯作者：
Miyashita, M.
中科院分区：
文献类型：
--
作者：
Broom, D. R.;Stensel, D. J.;Miyashita, M.
Ghrelin是一种由胃和其他组织中的内分泌细胞分泌的促食欲激素。胃饥饿素的酰化对于食欲调节是必不可少的。剧烈运动会引起食欲抑制，但这似乎与总生长激素释放肽的抑制浓度无关。本研究探讨了运动和喂养对血浆酰化Ghrelin和食欲的影响。9名19-25岁的男性受试者参加了两项研究。随机交叉设计的9小时试验（运动和对照）。在一夜禁食后，审判于上午8时开始。在运动试验中，受试者在0800至0900之间以最大摄氧量的72%跑步60分钟。在此之后，他们休息了8小时，并在1100消耗了测试餐。在对照试验中，受试者休息9小时，并在1100时食用测试餐。与对照试验相比，血浆酰化生长素释放肽浓度的曲线下面积值（从静脉血样中评估）在运动试验的前3小时和整个9小时内较低：317 +/- 135 vs. 510 +/- 186 pg（.）ml（-1.）3 h和917 +/- 342 vs. 1，401 +/- 521 pg（.）ml（-1.）9 h（平均值+/-SE）（P < 0.05）。饥饿曲线下面积值（使用视觉量表评估）在运动试验的前3小时内低于对照试验（P = 0.013）。这些发现表明，血浆酰化生长素释放肽浓度和饥饿在跑步过程中受到抑制。
Ghrelin is an orexigenic hormone secreted from endocrine cells in the stomach and other tissues. Acylation of ghrelin is essential for appetite regulation. Vigorous exercise induces appetite suppression, but this does not appear to be related to suppressed concentrations of total ghrelin. This study examined the effect of exercise and feeding on plasma acylated Ghrelin and appetite. Nine male subjects aged 19-25 yr participated in two. 9-h trials (exercise and control) in a random crossover design. Trials began at 0800 in the morning after an overnight fast. In the exercise trial, subjects ran for 60 min at 72% of maximum oxygen uptake between 0800 and 0900. After this, they rested for 8 h and consumed a test meal at 1100. In the control trial, subjects rested for 9 h and consumed a test meal at 1100. Area under the curve values for plasma acylated ghrelin concentration (assessed from venous blood samples) were lower over the first 3 h and the full 9 h of the exercise trial compared with the control trial: 317 +/- 135 vs. 510 +/- 186 pg(.)ml(-1.)3 h and 917 +/- 342 vs. 1,401 +/- 521 pg(.)ml(-1.)9 h (means +/- S E) respectively (P < 0.05). Area under the curve values for hunger (assessed using a visual scale) were lower over the first 3 h of the exercise trial compared with the control trial (P = 0.013). These findings demonstrate that plasma acylated ghrelin concentration and hunger are suppressed during running.