The Impact of Harsh Parenting on the Development of Obesity in Adulthood: An Examination of Epigenetic/Gene Expression Mediators Among African American Youth.
The Impact of Harsh Parenting on the Development of Obesity in Adulthood: An Examination of Epigenetic/Gene Expression Mediators Among African American Youth.
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DOI：
10.3389/fcvm.2021.755458
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发表时间：
2021
影响因子：
3.6
通讯作者：
Ye K
中科院分区：
文献类型：
--
作者：
Lei MK;Beach SRH;Simons RL;Ye K
目的：我们在非裔美国青年中研究了青春期严苛的父母教育与成年后的体重指数(BMI)之间的关系。我们还评估了肥胖相关基因甲基化和肥胖的基因表达标记物作为这种关联的媒介的作用，为早期严苛父母教育的生物嵌入及其对年轻人健康的长期影响提供了一条途径。方法：以362名非裔美国青年为样本，在10-15岁时评估严苛的父母教养方式，在10岁和29岁时评估BMI，并在29岁时评估肥胖基因的DNA甲基化(DNaM)和基因表达。中介分析使用Bootstrap方法来生成可信区间。结果：控制了肥胖的遗传风险和与健康相关的协变量，儿童和青春期严厉的父母教育与10-29岁期间体重指数(ΔBMI)的变化有关。此外，我们还发现，严厉的父母教养方式对Δ体重指数的间接影响是通过肥胖相关的dNaM中介的，占总影响的45.3%。此外，肥胖相关dNaM介导了严厉的父母教养对肥胖相关基因(GEOG)基因表达的影响，而GEOG又介导了肥胖相关dNaM对Δ体重指数的影响。这一途径占总效应的3.4%。在这种间接影响的大小上没有性别差异。结论：研究结果表明，甲基化和基因表达的改变介导了严厉的父母教养方式对从童年到成年的肥胖变化的影响，说明了从严厉的父母教育到肥胖的合理的生物学途径，并支持了这样的假设，即儿童和青少年时期的严厉的父母教育可以从生物学上嵌入并导致肥胖。
Objective: We examined the association of prospectively assessed harsh parenting during adolescence with body mass index (BMI) in young adulthood among African American youth. We also assessed the role of methylation of obesity-related genes and gene expression markers of obesity as mediators of this association, providing a pathway for the biological embedding of early harsh parenting and its long-term impact on young adult health. Methods: Hypotheses were tested with a sample of 362 African American youth for whom harsh parenting was assessed at ages 10–15, BMI was assessed at age 10 and 29, and both DNA methylation (DNAm) and gene expression of obesity genes were assessed at age 29. Mediational analyses were conducted using bootstrap methods to generate confidence intervals. Results: Controlling for genetic risk for obesity and health-related covariates, harsh parenting across childhood and adolescence was associated with change in BMI (Δ BMI) from ages 10–29. In addition, we found that the indirect effect of harsh parenting on Δ BMI was mediated through obesity-related DNAm and accounted for 45.3% of the total effect. Further, obesity-related DNAm mediated the effect of harsh parenting on gene expression of obesity-related genes (GEOG), and GEOG, in turn, mediated the impact of obesity-related DNAm on ΔBMI. This pathway accounted for 3.4% of the total effect. There were no gender differences in the magnitude of this indirect effect. Conclusions: The results suggest that alterations in methylation and gene expression mediate the impact of harsh parenting on change in obesity from childhood to young adulthood, illustrating plausible biological pathways from harsh parenting to obesity and bolstering the hypothesis that harsh parenting in childhood and adolescence can become biologically embedded and contribute to obesity.
影响因子：
3.7
作者：
Plume JM;Beach SR;Brody GH;Philibert RA
通讯作者：
Philibert RA