OLFACTORY INPUT TO THE HIPPOCAMPUS OF THE CAT - FIELD POTENTIAL ANALYSIS
OLFACTORY INPUT TO THE HIPPOCAMPUS OF THE CAT - FIELD POTENTIAL ANALYSIS
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DOI：
10.1016/0006-8993(80)90829-x
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发表时间：
1980-01-01
期刊：
影响因子：
2.9
通讯作者：
MOLLEVANGER, WJ
中科院分区：
文献类型：
--
作者：
HABETS, AMMC;LOPESDASILVA, FH;MOLLEVANGER, WJ
在氟烷麻醉下的急性实验和长期留置电极的清醒猫中，研究了猫对梨状前皮质电刺激的海马反应。场电位和单位活动的分析表明，在何种程度上不同的海马亚区被激活，在其中发生的突触行动和动态的诱发反应的层状水平。在梨状前皮质刺激后，海马中诱发反应的主要发生器位于齿状筋膜和CA 3（CA 1锥体细胞，可能还有下托细胞，被激活，但程度较低）。最初的突触活动发生在齿状筋膜颗粒细胞和CA3锥体细胞树突的最远端。这种突触活动对应于EPSP（兴奋性突触后电位），导致海马单位放电率的短暂增加，随后放电率通常会持续下降。从梨状前皮质经外侧内嗅皮质到海马神经元的通路可能使嗅觉输入有效地兴奋海马神经元。
Hippocampal responses to electrical stimulation of the prepyriform cortex in the cat were studied in acute experiments under halothane anesthesia and in awake cats with chronically indwelling electrodes. Analysis of field potentials and unit activity indicated the extent to which different hippocampal subareas were activated, the laminar level at which the synaptic action took place and the dynamics of the evoked responses. The main generator of evoked responses in the hippocampus upon prepyriform cortex stimulation is localized in the fascia dentata and CA3 (CA1 pyramidal cells, and probably subiculum cells, are activated but in a lesser degree). The initial synaptic activity takes place at the most distal part of the dendrites of fascia dentata granule cells and CA3 pyramidal cells. This synaptic activity corresponds to an EPSP [excitatory postsynaptic potential] that leads to a transient increase in the firing rate of the hippocampal units, which is often followed by a long-lasting decrease in firing rate. The pathway from the prepyriform cortex via lateral entorhinal cortex to hippocampal neurons may enable olfactory inputs to effectively excite hippocampal neurons.