Carcinogenicity of human papillomaviruses
Carcinogenicity of human papillomaviruses
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DOI：
10.1016/s1470-2045(05)70086-3
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发表时间：
2005-04-01
期刊：
影响因子：
51.1
通讯作者：
El Ghissassi, F
中科院分区：
文献类型：
--
作者：
Cogliano, V;Baan, R;El Ghissassi, F
2005年2月，来自13个国家的25名科学家（小组）在国际癌症研究机构（IARC；法国里昂）举行会议，重新评估人乳头瘤病毒的致癌性。 1 几乎所有宫颈癌病例中都存在致癌人乳头瘤病毒的持续感染，宫颈癌是全世界女性中第二常见的癌症，2000 年新增病例近 471,000 例，死亡人数为 233 000 例。2 约 80% 的病例发生在没有适当筛查计划的发展中国家。人乳头瘤病毒感染人类粘膜和皮肤组织。生殖器人乳头瘤病毒感染的患病率因国家而异（女性为 1-40%）。尽管大多数感染会在 2 年内消退，但持续的生殖器人乳头瘤病毒感染可导致癌症，包括宫颈癌。通过使用检测病毒 DNA 的检测方法可以可靠地记录人乳头瘤病毒的感染。研究已将特定类型的人乳头瘤病毒与宫颈癌或宫颈上皮内瘤变 3 期 (CIN3)（浸润性宫颈癌的前兆）联系起来。针对人乳头瘤病毒感染的预防性疫苗接种可能很快就会实现。更遥远的目标是开发治疗性疫苗作为与人乳头瘤病毒相关的感染或癌症的辅助治疗。
In February, 2005, 25 scientists from 13 countries (panel) met at the International Agency for Research on Cancer (IARC; Lyon, France) to reassess the carcinogenicity of human papillomaviruses. 1 Persistent infection with a carcinogenic human papillomavirus is found in virtually all cases of cervical cancer—the second most common cancer in women worldwide, with almost 471000 new cases and 233 000 deaths in 2000. 2 About 80% of cases occur in developing countries that do not have adequate screening programmes.Human papillomaviruses infect human mucosal and cutaneous tissues. The prevalence of genital human papillomavirus infection varies between countries (1–40% in women). Although most infections resolve within 2 years, persistent genital human papillomavirus infection can lead to cancer, including cervical cancer. Infection with human papillomavirus is reliably recorded by use of assays that detect viral DNA. Studies have associated specific types of human papillomavirus with cervical cancer or cervical intraepithelial neoplasia stage 3 (CIN3), a precursor to invasive cervical cancer. Prophylactic vaccination against human papillomavirus infection might be realised shortly. A more distant goal is to develop therapeutic vaccines as adjuvant treatment for infections or cancers associated with human papillomavirus.