COMPARISON OF EFFECTS OF LAURIC ACID AND PALMITIC ACID ON PLASMA-LIPIDS AND LIPOPROTEINS
COMPARISON OF EFFECTS OF LAURIC ACID AND PALMITIC ACID ON PLASMA-LIPIDS AND LIPOPROTEINS
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DOI：
10.1093/ajcn/56.5.895
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发表时间：
1992-11-01
影响因子：
7.1
通讯作者：
GRUNDY, SM
中科院分区：
文献类型：
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作者：
DENKE, MA;GRUNDY, SM
在14名男性的代谢-饮食研究中，通过采用液体配方饲料，以随机顺序各喂养3周，比较了月桂酸（C12：0）、棕榈酸（C16：0）和油酸（C18：1）对血脂和脂蛋白的影响。月桂酸由合成的高月桂酸油提供，棕榈酸由棕榈油提供，油酸由富含油酸的向日葵籽油提供。高月桂酸油导致血浆总胆固醇浓度较高（4.94 +/- 0.75 mmol/L [xBAR +/- SE]）和LDL胆固醇（3.70 +/- 0.57 mmol/L），与高油酸向日葵籽油相比（分别为4.44 +/- 0.54和3.31 +/- 0.44 mmol/L），但没有像棕榈油那样增加总胆固醇和LDL胆固醇浓度（分别为5.17 ± 0.65和3.93 ± 0.51 mmol/L）。血浆甘油三酯或HDL胆固醇无差异。与油酸相比，月桂酸可提高总胆固醇和低密度脂蛋白胆固醇浓度，但不像棕榈酸那样有效地提高胆固醇浓度。
The effects of lauric acid (C12:0) on plasma lipids and lipoproteins were compared with the effects of palmitic acid (C16:0) and oleic acid (C18:1) in a metabolic-diet study of 14 men by using liquid-formula diets fed for 3 wk each in random order. Lauric acid was supplied in a synthetic high-lauric oil, palmitic acid was provided by palm oil and oleic acid in oleic-rich sunflower seed oil. The high-lauric oil resulted in higher concentrations of plasma total cholesterol (4.94 +/- 0.75 mmol/L [xBAR +/- SE]) and LDL cholesterol (3.70 +/- 0.57 mmol/L) when compared with high-oleic sunflower oil (4.44 +/- 0.54 and 3.31 +/- 0.44 mmol/L, respectively), but did not raise total and LDL cholesterol concentrations as much as did palm oil (5.17 +/- 0.65 and 3.93 0.51 mmol/L, respectively). No differences were noted in plasma triglycerides or HDL cholesterol. Lauric acid raises total and LDL cholesterol concentrations compared with oleic acid, but is not as potent for increasing cholesterol concentrations as is palmitic acid.