Meta-Analyst: software for meta-analysis of binary, continuous and diagnostic data.
Meta-Analyst: software for meta-analysis of binary, continuous and diagnostic data.
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DOI：
10.1186/1471-2288-9-80
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发表时间：
2009-12-04
影响因子：
4
通讯作者：
Trikalinos TA
中科院分区：
文献类型：
--
作者：
Wallace BC;Schmid CH;Lau J;Trikalinos TA
荟萃分析越来越多地被用作证据合成的一个关键来源，为临床实践提供信息。元分析的理论和统计学基础不断发展，为许多新的和具有挑战性的问题提供了解决方案。在实践中，大多数元分析是在一般统计程序或专门的元分析程序中进行的。在这里，我们介绍Meta-Analyst，一个新颖的，强大的，直观的，免费的元分析程序，用于各种问题的元分析。Meta-Analyst是在Microsoft.NET框架之上用C#实现的，具有图形用户界面。该软件对二元和连续结果进行几个元分析和元回归模型，并在频数和贝叶斯框架内对诊断和预后测试研究进行分析。此外，Meta-Analyst包括一个灵活的工具，可以编辑和定制生成的荟萃分析图表(例如，森林图)，并提供多种格式的输出(图像、Adobe PDF、Microsoft Word-Ready RTF)。采用的软件体系结构允许对图形用户界面(GUI)或分析模块进行快速更改。我们通过将Meta-Analyst的输出与Stata中标准元分析例程的输出进行比较，验证了Meta-Analyst的数值精度。该数据库包含11,803个二元结果数据的元分析，以及来自Cochrane系统综述图书馆的6,881个连续结果数据的元分析。诊断和预后测试研究的分析结果已经在与MetaDisc和MetaTest进行的有限数量的Meta分析中得到验证。贝叶斯统计分析使用OpenBUGS计算引擎(因此与独立的OpenBUGS软件一样准确)。我们已经开发并验证了一个新的进行荟萃分析的程序，该程序结合了现有软件的优势来完成这项任务。
Meta-analysis is increasingly used as a key source of evidence synthesis to inform clinical practice. The theory and statistical foundations of meta-analysis continually evolve, providing solutions to many new and challenging problems. In practice, most meta-analyses are performed in general statistical packages or dedicated meta-analysis programs. Herein, we introduce Meta-Analyst, a novel, powerful, intuitive, and free meta-analysis program for the meta-analysis of a variety of problems. Meta-Analyst is implemented in C# atop of the Microsoft .NET framework, and features a graphical user interface. The software performs several meta-analysis and meta-regression models for binary and continuous outcomes, as well as analyses for diagnostic and prognostic test studies in the frequentist and Bayesian frameworks. Moreover, Meta-Analyst includes a flexible tool to edit and customize generated meta-analysis graphs (e.g., forest plots) and provides output in many formats (images, Adobe PDF, Microsoft Word-ready RTF). The software architecture employed allows for rapid changes to be made to either the Graphical User Interface (GUI) or to the analytic modules. We verified the numerical precision of Meta-Analyst by comparing its output with that from standard meta-analysis routines in Stata over a large database of 11,803 meta-analyses of binary outcome data, and 6,881 meta-analyses of continuous outcome data from the Cochrane Library of Systematic Reviews. Results from analyses of diagnostic and prognostic test studies have been verified in a limited number of meta-analyses versus MetaDisc and MetaTest. Bayesian statistical analyses use the OpenBUGS calculation engine (and are thus as accurate as the standalone OpenBUGS software). We have developed and validated a new program for conducting meta-analyses that combines the advantages of existing software for this task.
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影响因子：
7.2
作者：
Terrin, N;Schmid, CH;Lau, J
通讯作者：
Lau, J
影响因子：
4
作者：
Bax, Leon;Yu, Ly-Mee;Moons, Karel G. M.
通讯作者：
Moons, Karel G. M.
影响因子：
14.6
作者：
Ioannidis, John P. A.;Trikalinos, Thomas A.
通讯作者：
Trikalinos, Thomas A.
影响因子：
2
作者：
van Houwelingen, HC;Arends, LR;Stijnen, T
通讯作者：
Stijnen, T
影响因子：
2
作者：
Rutter, CM;Gatsonis, CA
通讯作者：
Gatsonis, CA