Quantifying nerve architecture in murine and human airways using three-dimensional computational mapping.
Quantifying nerve architecture in murine and human airways using three-dimensional computational mapping.
复制标题
使用三维计算映射量化小鼠和人类气道的神经结构。
DOI：
10.1165/rcmb.2012-0290ma
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发表时间：
2013
影响因子：
6.4
通讯作者：
Jacoby,DavidB
中科院分区：
文献类型：
--
作者：
Scott,GregoryD;Fryer,AllisonD;Jacoby,DavidB
The quantitative histological analysis of airway innervation using tissue sections is challenging because of the sparse and patchy distribution of nerves. Here we demonstrate a method using a computational approach to measure airway nerve architecture that will allow for more complete nerve quantification and the measurement of structural peripheral neuroplasticity in lung development and disease. We demonstrate how our computer analysis outperforms manual scoring in quantifying three-dimensional nerve branchpoints and lengths. In murine lungs, we detected airway epithelial nerves that have not been previously identified because of their patchy distribution, and we quantified their three-dimensional morphology using our computer mapping approach. Furthermore, we show the utility of this approach in bronchoscopic forceps biopsies of human airways, as well as the esophagus, colon, and skin.
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DOI：
10.1164/ajrccm.152.6.8520777
发表时间：
1995-12-01
影响因子：
24.7
作者：
OCONNELL, F;SPRINGALL, DR;PRIDE, NB
通讯作者：
PRIDE, NB
哮喘中的气道结构：共聚焦显微镜的作用？
影响因子：
3.2
作者：
R. Goldie;L. Fernandes;P. Rigby;C. J. Pudney;L. Spalding;B. O'connor;C. Page
通讯作者：
C. Page
影响因子：
5.5
作者：
Oh, Yong-Seog;Jong, Ambrose Y.;Chen, Lan S.
通讯作者：
Chen, Lan S.
DOI：
10.1002/ar.a.10007
发表时间：
2003-01-01
期刊：
ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY
影响因子：
--
作者：
Adriaensen, D;Brouns, I;Timmermans, JP
通讯作者：
Timmermans, JP
影响因子：
82.9
作者：
Kerschensteiner, M;Schwab, ME;Misgeld, T
通讯作者：
Misgeld, T