Conjugate Addition of 1,3-Dicarbonyl Compounds to Maleimides Using a Chiral C2-Symmetric Bis(2-aminobenzimidazole) as Recyclable Organocatalyst
Conjugate Addition of 1,3-Dicarbonyl Compounds to Maleimides Using a Chiral C2-Symmetric Bis(2-aminobenzimidazole) as Recyclable Organocatalyst
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DOI：
10.1021/ol202599h
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发表时间：
2011-11-18
期刊：
影响因子：
5.2
通讯作者：
Najera, Carmen
中科院分区：
文献类型：
--
作者：
Gomez-Torres, Eduardo;Alonso, Diego A.;Najera, Carmen
可回收的手性2-氨基苯并咪唑衍生的有机催化剂如果有效地促进1，3-二酮、β-酮酯和丙二酸酯对马来酰亚胺和N-取代的马来酰亚胺的室温不对称共轭加成，即使在克级也以优异的产率和对映选择性提供相应的Michael加合物。
The recyclable chiral 2-aminobenzimidazole-derived organocatalyst if efficiently promotes the room temperature asymmetric conjugate addition of 1,3-diketones, beta-ketoesters, and malonates to maleimide and N-substituted maleimides, affording the corresponding Michael adducts in excellent yields and enantioselectivities even at gram scale.