Increased incidence of non-insulin-dependent diabetes mellitus among adolescents
Increased incidence of non-insulin-dependent diabetes mellitus among adolescents
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DOI：
10.1016/s0022-3476(96)80124-7
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发表时间：
1996-05-01
影响因子：
5.1
通讯作者：
Zeitler, P
中科院分区：
文献类型：
--
作者：
PinhasHamiel, O;Dolan, LM;Zeitler, P
目的：为了确定儿童人群中非胰岛素依赖型糖尿病（NIDDM）诊断的增加是否与成人人群中肥胖的增加一样。研究设计：从1982年到1995年，在一个地区，根据美国国家糖尿病数据组的标准，对大学附属儿科糖尿病转诊中心的2000名儿童进行了回顾和分类。在1992年之前，从出生到19岁的患者中，诊断为NIDDM的患者数量从约4%的新诊断糖尿病上升，1994年为16%。在10至19岁的患者中，NIDDM占1994年糖尿病诊断的33%。大辛辛那提地区青少年NIDDM的发病率增加了10倍，从1982年的每年0.7/100，000增加到1994年的每年7.2/100，000。就诊时的平均（+/- SD）年龄和体重指数分别为13.8 +/- 1.9岁和37.7 +/- 9.6 kg/m2。总体女性/男性比例为1.7：1，女性患者比男性患者早1年就诊男性体重指数高于女性（p < 0.01）（p < 0.05），65%的患者有NIDDM一级亲属，21%的患者在就诊时至少有一种与肥胖相关的其他疾病。在大辛辛那提的青少年中，NIDDM的发病率越来越高，伴随着全国青少年肥胖的上升，肥胖和NIDDM家族史是NIDDM的重要危险因素。由于NIDDM导致长期发病，因此预防肥胖以及早期发现显性疾病至关重要。
Objective: To determine whether a rise in the diagnosis of non-insulin-dependent diabetes mellitus (NIDDM) has accompanied the rise in obesity in the pediatric population, as it has among adults.Study design: Medical records of 1027 consecutive patients from birth to age 19 years with a diagnosis of diabetes from 1982 to 1995 at a regional, university-affiliated pediatric diabetes referral center were reviewed and classified according to criteria of the National Diabetes Data Group.Results: The number of patients with a diagnosis of NIDDM rose from approximately 4% of new diagnoses of diabetes in patients from birth to age 19 years before 1992, to 16% in 1994. Among patients 10 to 19 years of age, NIDDM accounted for 33% of diagnoses of diabetes in 1994. The incidence of adolescent NIDDM in Greater Cincinnati increased tenfold, from 0.7/100,000 per year in 1982 to 7.2/100.000 per year in 1994. The mean (+/- SD) age and body mass index at presentation were 13.8 +/- 1.9 years and 37.7 +/- 9.6 kg/m(2), respectively. The overall female/male ratio was 1.7:1, and female patients were seen 1 year earlier than male patients (p < 0.01), Male subjects had a higher body mass index than female subjects (p < 0.05), A first-degree relative with NIDDM was identified for 65% of patients, At presentation, 21% of the patients had had a diagnosis of at least one other condition associated with obesity.Conclusion: There is an increasing incidence of NIDDM among adolescents in Greater Cincinnati, accompanying the national rise in adolescent obesity, Obesity and strong family histories of NIDDM are important risk factors, Because NIDDM leads to long-term morbidity, the prevention of obesity, as well as early identification of overt disease, is critical.