The in-flow capture of superparamagnetic nanoparticles for targeting therapeutics
The in-flow capture of superparamagnetic nanoparticles for targeting therapeutics
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DOI：
10.1016/j.nano.2007.11.001
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发表时间：
2008-03-01
影响因子：
5.4
通讯作者：
Mackley, Malcolm R.
中科院分区：
文献类型：
--
作者：
Darton, Nicholas J.;Hallmark, Bart;Mackley, Malcolm R.
超顺磁性纳米颗粒已经被合成，可能被用于体内的磁靶向疗法。使用0.5T磁体成功地实现了330 nm和580 nm磁铁纳米颗粒的磁靶向和流动捕获。微毛细管流中磁性纳米颗粒捕获的光学观察为磁捕获与血管直接相关的纳米颗粒提供了一种有用的初步方法。当平均毛细管流速达到2.5 cm S(1)和330 nm团聚体在平均流速4.4 cm S(1)时，可以形成稳定的580 nm团聚体纳米颗粒层。这些数据表明，较小的纳米颗粒凝聚体形成了一层不受流体剪切侵蚀的层。在这些实验中，没有检测到纳米颗粒对毛细血管的阻塞，类似于血栓。(C)2008 Elsevier Inc.保留所有权利。
Superparamagnetic nanoparticles have been synthesized that could potentially be used to magnetically target therapeutics within the body. The magnetic targeting and successful in-flow capture of 330-nm and 580-nm agglomerates of these magnetite nanoparticles was performed using a 0.5-T magnet. Optical observation of magnetic nanoparticle capture in microcapillary flow provides a useful preliminary way of establishing conditions for the magnetic capture of nanoparticles with direct relevance to blood vessels for magnetically directed therapy. A stable nanoparticle layer of 580-nm agglomerates could be formed at mean capillary flow velocities of up to 2.5 cm s (1) and for the 330-nm agglomerates at velocities up to 4.4 cm s (1). These data show that smaller nanoparticle agglomerates form a layer that is impervious to erosion by fluid shear. Capillary blocking by nanoparticles, analogous to an embolism, was not detected in these experiments. (c) 2008 Elsevier Inc. All rights reserved.