Uremia-Associated Immunological Aging and Severity of COVID-19 Infection.
Uremia-Associated Immunological Aging and Severity of COVID-19 Infection.
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DOI：
10.3389/fmed.2021.675573
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发表时间：
2021
影响因子：
3.9
通讯作者：
Betjes MGH
中科院分区：
文献类型：
--
作者：
Betjes MGH
COVID-19大流行开始一年后，很明显，某些群体的个体面临着复杂感染过程的特别高风险，导致高发病率和死亡率。两个具体的风险因素是最突出的，即老年和合并症的存在。最近的研究表明，肾功能受损的患者，特别是那些接受肾脏替代治疗或接受肾脏移植的患者，患严重COVID感染的风险要高得多，死亡率也会增加。这可能部分是由于这些患者中合并症的患病率增加，但反映过早免疫老化的免疫系统的特定改变可能同样重要。在这篇综述中，就COVID 19感染对尿毒症相关免疫衰老的不同方面，特别是胸腺功能和记忆T细胞扩增进行了综述。从本质上讲，幼稚T细胞的产生减少可能有助于次优的抗病毒免疫应答，而效应T细胞的相对不受控制的扩增可能促进COVID-19感染的可怕阶段，肺实质的过度和危及生命的炎症。
One year after the start of the COVID-19 pandemic it has become clear that some groups of individuals are at particular high risk of a complicated course of infection resulting in high morbidity and mortality. Two specific risk factors are most prominent, old age and the presence of co-morbidity. Recent studies have shown that patients with compromised renal function, especially those treated with renal replacement therapy or having received a kidney transplant are at a much higher risk for severe COVID infection and increased mortality. This may be in part due to the increased prevalence of co-morbid conditions in these patients but specific alterations in their immune system, reflecting premature immunological aging, may be equally important. In this review the different aspects, in particular thymus function and memory T cell expansion, of uremia-associated immunological aging are reviewed with respect to COVID 19 infection. In essence, the decreased generation of naïve T cells may be instrumental in suboptimal anti-viral immune responses while the relatively uncontrolled expansion of effector T cells may facilitate the feared phase of the COVID-19 infection with excessive and live-threatening inflammation of the lung parenchyma.
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影响因子：
7.9
作者：
Chiu, Yen-Ling;Shu, Kai-Hsiang;Chuang, Yi-Fang
通讯作者：
Chuang, Yi-Fang
影响因子：
20.3
作者：
Chu, YW;Memon, SA;Gress, RE
通讯作者：
Gress, RE
影响因子：
3.7
作者：
Betjes, Michiel G. H.;Litjens, Nicolle H. R.
通讯作者：
Litjens, Nicolle H. R.
循环中的 CD4(+)CD28null T 细胞可能会增加肾移植后不久发生动脉粥样硬化性血管事件的风险。
影响因子：
2.5
作者：
Betjes MG;Weimar W;Litjens NH
通讯作者：
Litjens NH
胸腺基质细胞：在胸腺萎缩和年龄相关功能障碍中的作用。
影响因子：
3.9
作者：
Cepeda S;Griffith AV
通讯作者：
Griffith AV