THE SEROLOGICAL RESPONSE OF YOUNG-DOGS TO THE FLURY-LEP STRAIN OF RABIES VIRUS-VACCINE
THE SEROLOGICAL RESPONSE OF YOUNG-DOGS TO THE FLURY-LEP STRAIN OF RABIES VIRUS-VACCINE
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DOI：
10.1007/bf00343220
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发表时间：
1990-01-01
影响因子：
2.2
通讯作者：
RUPPRECHT, CE
中科院分区：
文献类型：
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作者：
AGHOMO, HO;ODUYE, OO;RUPPRECHT, CE
测定了来自尼日利亚的幼犬对Flury低蛋代（LEP）狂犬病活疫苗的血清学应答。使用了两组幼犬：一组来自狂犬病疫苗接种的母犬，另一组来自未接种疫苗的母犬。用Flury LEP株狂犬病疫苗肌肉注射幼犬，从第4周到第30周连续采血。用改良的快速荧光灶抑制试验（RFFIT）检测血清狂犬病毒中和抗体（VNA）。未接种疫苗母犬的幼犬在第4周龄后至第10周龄对疫苗接种反应良好，显示VNA逐渐增加。相比之下，接种疫苗的母犬的幼犬仅在10周龄时对狂犬病疫苗接种反应良好，尽管可检测到的母体狂犬病VNA和狂犬病抗核糖核蛋白（RNP）抗体在产后6周时有所下降。
The serological response of puppies from Nigeria to live Flury low egg passage (LEP) rabies vaccine was determined. Two sets of puppies were used: one set from rabies-vaccinated bitches and another set from non-vaccinated bitches. Puppies were vaccinated intramuscularly with Flury LEP strain rabies vaccine and serially bled from the 4th week to the 30th week. Serum rabies virus neurtralizing antibodies (VNA) were measured by a modified rapid fluorescent focus inhibition test (RFFIT). Puppies from non-vaccinated bitches responded well to vaccination after the 4th week and through to the 10th week of age, showing a progressive increase in VNA. In contrast, puppies from vaccinated bitches responded well to rabies vaccination only at 10 weeks of age, although detectable maternal rabies VNA and rabies anti-ribonucleoprotein (RNP) antibodies had decreased by 6 weeks post partum.