Evaluation of the potential for olestra to affect the availability of dietary phytochemicals
Evaluation of the potential for olestra to affect the availability of dietary phytochemicals
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DOI：
10.1093/jn/127.8.1699s
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发表时间：
1997-08-01
影响因子：
4.2
通讯作者：
Peters, JC
中科院分区：
文献类型：
--
作者：
Cooper, DA;Webb, DR;Peters, JC
据推测，水果和蔬菜中发现的植物化学物质是导致水果和蔬菜含量高的饮食与某些慢性疾病和癌症风险之间负相关的原因，本文评估了olestra影响膳食植物化学物质吸收的可能性，并估计了当含有olestra的零食和含有类胡萝卜素的食物被自由食用时，olestra对类胡萝卜素可用性的影响。关于olestra对29种化合物（主要是营养素和口服药物）的可用性的影响的实验数据汇编表明，olestra仅影响辛醇-水分配系数大于7.5的分子的可用性。为382种膳食植物化学物质编制的分配系数表明，只有两类植物化学物质，植物甾醇和类胡萝卜素，含有分子的辛醇-水分配系数的范围内，其中olestra可能会影响生物利用度。对植物甾醇生物利用度的潜在影响是
It has been hypothesized that phytochemicals found in fruits and vegetables are responsible for the inverse association observed between diets high in fruits and vegetables and risk of certain chronic diseases and cancer, This paper assesses the potential for olestra to affect the absorption of dietary phytochemicals and estimates the effect of olestra on the availability of carotenoids when olestra-containing snacks and foods containing carotenoids are eaten in free-living diets, Experimental data compiled on the effects of olestra on the availability of 29 compounds, mainly nutrients and oral medications, showed that olestra affects the availability of only molecules having octanol-water partition coefficients greater than similar to 7.5. Partition coefficients compiled for 382 dietary phytochemicals showed that only two classes of phytochemicals, phytosterols and carotenoids, contain molecules with octanol-water partition coefficients in the range in which olestra could potentially affect bioavailability. The potential effect on the bioavailability of phytosterols would be