ROLE OF TRYPTOPHAN IN GAMMA-INTERFERON-MEDIATED CHLAMYDIAL PERSISTENCE
ROLE OF TRYPTOPHAN IN GAMMA-INTERFERON-MEDIATED CHLAMYDIAL PERSISTENCE
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DOI：
10.1111/j.1749-6632.1994.tb44274.x
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发表时间：
1994-01-01
期刊：
影响因子：
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通讯作者：
BYRNE, GI
中科院分区：
文献类型：
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作者：
BEATTY, WL;BELANGER, TA;BYRNE, GI
Truchomutis是一种重要的人类专性细胞内病原体，可引起相当大比例的眼部和性传播疾病。反复感染会促进慢性炎症，导致与失明和不育相关的疤痕。衣原体1的持续存在也被认为通过提供延长的抗原刺激而增强疾病过程，导致免疫病理学后遗症。γ干扰素（IFN-γ）是负责抑制细胞内衣原体生长和产生持续衣原体发展的免疫效应分子。IFN-γ通过诱导吲哚胺2，3-双加氧酶（IDO）抑制衣原体生长，IDO是一种与色氨酸降解相关的非组成型酶。IFN-γ介导的宿主细胞活化以限制细胞内衣原体发育需要相对大量的细胞因子。持续性的诱导发生在IFN-γ的量大大减少时，并且持续性的特征在于存在形态学和生物化学上独特形式的衣原体。这些扩大的异常衣原体形式是非感染性的，并表现出改变的关键衣原体蛋白质的表达，如结构成分（主要外膜蛋白[MOMP]，60 kD外膜蛋白和脂多糖）的水平降低，并继续合成热休克蛋白60，与局部免疫病理变化相关的应激蛋白。'
Chhmydiu truchomutis is an important human obligate intracellular pathogen responsible for a significant proportion of ocular and sexually transmitted diseases. Repeated infection promotes chronic inflammation which contributes to scarring associated with blindness and infertility. Chlamydia1 persistence also is thought to augment the disease process by providing prolonged antigenic stimulation, leading to immunopathologic sequelae.Gamma interferon (IFN-y) is an immune effector molecule responsible for inhibiting intracellular chlamydial growth and the generation of persistent chlamydial development. IFN-y inhibits chlamydial growth by induction of indoleamine 2, 3-dioxygenase (IDO), a nonconstitutive enzyme associated with tryptophan degradation.'IFN-y-mediated activation of host cells to restrict intracellular chlamydial development requires relatively large amounts of the cytokine. Induction of persistence occurs at greatly reduced amounts of IFN-y, and persistence is characterized by the presence of morphologically and biochemically unique forms of chlamydiae.* These enlarged, aberrant chlamydial forms are noninfectious and exhibit altered expression in key chlamydial proteins, such as decreased levels of structural constituents (the major outer membrane protein [MOMP], 60-kD outer membrane protein, and lipopolysaccharide) and continued synthesis of hsp60, a stress protein associated with local immunopathologic changes.'