SOX5 promotes epithelial-mesenchymal transition and cell invasion via regulation of Twist1 in hepatocellular carcinoma
SOX5 promotes epithelial-mesenchymal transition and cell invasion via regulation of Twist1 in hepatocellular carcinoma
复制标题
SOX5通过调节肝细胞癌中的Twist1促进上皮-间质转化和细胞侵袭
DOI：
10.1007/s12032-014-0461-2
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发表时间：
2015-02-01
期刊：
影响因子：
3.4
通讯作者：
Li, Xiangcheng
中科院分区：
文献类型：
--
作者：
Wang, Dong;Han, Sheng;Li, Xiangcheng
转录因子性别决定区Y-box蛋白5（SOX 5）在多种类型的癌症中起重要作用。然而，SOX 5在肝细胞癌（HCC）中的表达和功能尚未阐明。在这里，我们发现SOX 5在HCC组织和细胞系中显著上调。获得和丧失功能的研究表明，SOX 5促进HCC细胞的迁移和侵袭。此外，我们发现SOX 5通过调节Twist 1与上皮-间质转化（EMT）有关。我们的研究结果首次表明，SOX 5是一种新的调节EMT在肝癌，并可能是一个潜在的治疗肝癌转移的目标。
The transcription factor sex determining region Y-box protein 5 (SOX5) plays important roles in various types of cancers. However, the expression and function of SOX5 in hepatocellular carcinoma (HCC) have not been elucidated. Here, we found that SOX5 is significantly up-regulated in HCC tissues and cell lines. Gain-and loss-of-function studies demonstrated that SOX5 promoted HCC cell migration and invasion. In addition, we revealed that SOX5 is linked to epithelial-mesenchymal transition (EMT) by regulation of Twist1. Our results indicate for the first time that SOX5 is a novel regulator of EMT in HCC and may be a potential therapeutic target for HCC metastasis.